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Volume 29, Number 7—July 2023
Research Letter

Extensively Drug-Resistant Shigella flexneri 2a, California, USA, 2022

J.R. Caldera, Shangxin Yang, and Daniel Z. UslanComments to Author 
Author affiliation: David Geffen School of Medicine at University of California, Los Angeles, California, USA

Main Article

Table

AST profile for extensively drug-resistant Shigella flexneri 2a isolate UCLA_1207, 2023, from patient in California, USA*

Drug MIC, mcg/mL Interpretation Detected AMR gene
Amoxicillin + clavulanate 32 Resistant† blaOXA-1, blaCTX-M-15
Ampicillin >32 Resistant† blaOXA-1, blaCTX-M-15
Azithromycin 32 Resistant mph(A)
Cefazolin >32 Resistant† blaOXA-1, blaCTX-M-15
Cefepime 4 Susceptible, dose dependent† blaCTX-M-15
Ceftazidime 4 Susceptible† blaCTX-M-15
Ceftazidime/avibactam <2 Susceptible† None
Ceftriaxone 64 Resistant† blaCTX-M-15
Ciprofloxacin >4 Resistant qnrS1, gyrA D87N+S83L
Doxycycline >16 Resistant† tet(B)
Ertapenem <0.25 Susceptible† None
Imipenem <1 Susceptible† None
Levofloxacin >8 Resistant† qnrS1, gyrA D87N+S83L
Meropenem <0.25 Susceptible† None
Minocycline 4 Susceptible† tet(B)
Piperacillin + tazobactam <8 Susceptible† blaOXA-1, blaCTX-M-15
Trimethoprim/sulfamethoxazole >4/80 Resistant dfrA17, sul1
Fosfomycin Not performed‡ Not performed‡ Not applicable

*AMR, antimicrobial resistance; AST, antimicrobial susceptibility testing. †AST not initially included in primary report and performed and reported at physician request. ‡AST not performed because of lack of interpretive guidelines by the Clinical and Laboratory Standards Institute.

Main Article

Page created: May 19, 2023
Page updated: June 21, 2023
Page reviewed: June 21, 2023
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