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Volume 29, Number 8—August 2023
Synopsis

Outbreak of NDM-1– and OXA-181–Producing Klebsiella pneumoniae Bloodstream Infections in a Neonatal Unit, South Africa

Rindidzani E. Magobo, Husna Ismail, Michelle Lowe, Wilhelmina Strasheim, Ruth Mogokotleng, Olga Perovic, Stanford Kwenda, Arshad Ismail, Manala Makua, Abram Bore, Rose Phayane, Harishia Naidoo, Tanya Dennis, Makhosazane Ngobese, Wim Wijnant, Nelesh P. GovenderComments to Author , and for Baby GERMS-SA1
Author affiliations: National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, South Africa (R.E. Magobo, H. Ismail, M. Lowe, W. Strasheim, R. Mogokotleng, O. Perovic, S. Kwenda, A. Ismail, N.P. Govender); University of the Witwatersrand, Johannesburg (O. Perovic, N.P. Govender); National Department of Health, Pretoria (M. Makua); Gauteng Provincial Department of Health, Johannesburg (A. Bore); Tembisa Provincial Hospital, Johannesburg (R. Phayane, H. Naidoo, T. Dennis, M. Ngobese, W. Wijnant); University of Cape Town, Cape Town, South Africa (N.P. Govender); University of Exeter, Exeter, UK (N.P. Govender).

Main Article

Table

Clinical characteristics of WGS-confirmed cases of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in newborns admitted to the neonatal unit of a tertiary care hospital, South Africa, October 2019–February 2020*

Pt no. Age, d/sex Weight at birth, g Gestational age, wks Ward† Other pathogens Outcome Isolate Collection date ST K type O type
Pt 1
 13/F
 1,300
 32
 A
Transferred
 BG32
 2019 Oct 10
 307
 KL102
 O2afg
Pt 2
 31/M
 1,000
 28
 A
Discharged
 BG113
 2019 Oct 23
 17
 KL25
 O5
Pt 3
 0/M
 3,200
 42
 A
Discharged
 BG265
 2019 Oct 28
 17
 KL25
 O5
Pt 4
 7/M
 1,000
 28
 A1, B
 Acinetobacter baumannii
 Died
 BG314
 2019 Nov 15
 152
 KL149
 O4
Pt 5
 20/F
 890
 28
 A
Discharged
 BG315
 2019 Nov 27
 307
 KL102
 O2afg
Pt 6
 10/F
 1,360
 27
 A1, A2, B
 Enterobacter cloacae
 Died
 BG313
 2019 Nov 29
 297
 KL158
 O1
Pt 7
 2/M
 1,000
 NR
 A
 Acinetobacter baumannii
 Died
 BG263
 2019 Nov 30
 152
 KL149
 O4
Pt 8
 5/F
 1,700
 34
 A
Died
 BG264
 2019 Dec 2
 152
 KL149
 O4
Pt 9
 17/M
 1,100
 NR
 B
Died
 BG259
 2019 Dec 4
 307
 KL102
 O2afg
Pt 10
 9/M
 2,690
 38
 A
Died
 BG258
 2019 Dec 5
 307
 KL102
 O2afg
Pt 11
 23/M
 1,100
 28
 B
Died
 BG254
 2019 Dec 10
 307
 KL102
 O2afg
Pt 12
 7/M
 840
 26
 A1, isolation
Discharged
 BG255
 2019 Dec 11
 152
 KL149
 O4
Pt 13
 1/M
 NR
 NR
 A
Discharged
 BG222
 2019 Dec 16
 152
 KL149
 O4
Pt 14
 21/M
 1,570
 34
 A
Discharged
 BG218
 2019 Dec 17
 152
 KL149
 O4
Pt 15
 4/F
 3,050
 39
 A
Died
 BG213
 2019 Dec 17
 152
 KL149
 O4
Pt 16
 19/F
 970
 NR
 A
 Enterobacter cloacae
 Died
 BG223
 2019 Dec 19
 152
 KL149
 O4
Pt 17
 7/F
 800
 29
 A
Died
 BG219
 2019 Dec 20
 152
 KL149
 O4
Pt 18
 3/M
 1,300
 29
 A1
Died
 BG215
 2019 Dec 23
 152
 KL149
 O4
Pt 19
 3/F
 1,700
 34
 A
Discharged
 BG214
 2019 Dec 27
 152
 KL149
 O4
Pt 20
 6/M
 810
 29
 A2
Died
 BG442
 2019 Dec 30
 25
 KL2
 O1
Pt 21
 0/F
 1,670
 33
 A
Discharged
 BG272
 2020 Jan 3
 152
 KL149
 O4
Pt 22
 0/M
 1,100
 30
 A1, isolation
Discharged
 BG271
 2020 Jan 11
 152
 KL149
 O4
Pt 23
 8/M
 970
 30
 A1, isolation, B
Discharged
 BG460
 2020 Jan 16
 152
 KL149
 O4
Pt 24
 12/M
 1,240
 28
 A1, A2, B
Died
 BG316
 2020 Jan 20
 152
 KL149
 O4
Pt 25
 13/M
 1,010
 27
 A1, isolation, B
Discharged
 BG317
 2020 Jan 21
 307
 KL102
 O2afg
Pt 26 6/M 925 29 A1, B Died BG449 2020 Feb 2 152 KL149 O4

*The specimen type used for all patients was blood culture. NR, not recorded; Pt, patient; ST, sequence type; WGS, whole-genome sequencing. †Wards A1, A2, and Isolation are sections (cubicles) within ward A with a total approved bed capacity of 40.

Main Article

1Members of Baby GERMS-SA are listed at the end of this article.

Page created: June 22, 2023
Page updated: July 20, 2023
Page reviewed: July 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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