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Volume 29, Number 9—September 2023
CME ACTIVITY - Synopsis

Characteristics of Hard Tick Relapsing Fever Caused by Borrelia miyamotoi, United States, 2013–2019

David W. McCormick, Catherine M. Brown, Jenna Bjork, Kim Cervantes, Brenda Esponda-Morrison, Jason Garrett, Natalie Kwit, Abigail Mathewson, Charles McGinnis, Marco Notarangelo, Rebecca Osborn, Elizabeth Schiffman, Haris Sohail, Amy M. Schwartz, Alison F. Hinckley, and Kiersten J. KugelerComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (D.W. McCormick, A.M. Schwartz, A.F. Hinckley, K.J. Kugeler); Massachusetts Department of Public Health, Boston, Massachusetts, USA (C.M. Brown); Minnesota Department of Health, Minneapolis, Minnesota, USA (J. Bjork, E. Schiffman); New Jersey Department of Health, Trenton, New Jersey, USA (K. Cervantes); Connecticut Department of Public Health, Hartford, Connecticut, USA (B. Esponda-Morrison); Rhode Island Department of Health, Providence, Rhode Island, USA (J. Garrett, C. McGinnis); Vermont Department of Health, Burlington, Vermont, USA (N. Kwit); New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA (A. Mathewson, M. Notarangelo); Wisconsin Department of Health Services, Madison, Wisconsin, USA (R. Osborn); Maine Center for Disease Control and Prevention, Augusta, Maine, USA (H. Sohail)

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Table 3

Diagnostic results for confirmed and possible cases of hard tick relapsing fever caused by Borrelia miyamotoi reported by public health surveillance, United States, 2013–2019*

Characteristic Confirmed, n = 166† Possible, n = 134
PCR results
Detected 162/164 (99) 0/5 (0)
Not detected
 0/164 (0)
 5/5 (100)
Serologic analysis results
Single IgM alone
Positive 2/2 (100) 36/127 (28)
Negative 0/2 (0) 89/127 (70)
Indeterminate 0/2 (0) 2/127 (2)
Single IgG alone
Positive 0/2 (0) 111/127 (87)
Negative 2/2 (100) 16/127 (13)
Indeterminate 0/2 (0) 0/127 (0)
Single combined IgM/IgG
Positive 1/2 (50) 6/7 (86)
Negative 0/2 (0) 1/7 (14)
Indeterminate 1/2 (50) 0/7 (0)
Paired serologic samples
>4-fold change in titer 1/1 (100) 0/18 (0)
<4-fold change in titer 0/1 (0) 18/18 (100)

*Values are no. positive/no. tested (%). †Missing diagnostic information for 2 cases.

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Page created: July 06, 2023
Page updated: August 18, 2023
Page reviewed: August 18, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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