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Volume 30, Number 1—January 2024

Research

Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016–2022

Pan Fu1Comments to Author , Jinlan Zhou1, Chao Yang, Yaxier Nijiati, Lijun Zhou, Gangfen Yan, Guoping Lu, Xiaowen ZhaiComments to Author , and Chuanqing WangComments to Author 
Author affiliations: National Children's Medical Center, Shanghai, China (P. Fu, J. Zhou, Y. Nijiati, L. Zhou, G. Yan, G. Lu, X. Zhai, C. Wang); Chinese Academy of Sciences, Shanghai (C. Yang)

Main Article

Figure 3

Changing macrolide resistance of circulating Bordetella pertussis strains, Shanghai, China, 2016–2022. A) ptxP3-strains showed very high resistance to macrolides after 2020. Resistance to macrolides was different in non-MT28 (0%) and MT28 (100%) isolates. B) Percentages of macrolide-sensitive BP, ptxP1-MRBP, and ptxP3-MRBP before and after 2020 show that ptxP1-MRBP strain was prevalent before 2020 but predominately ptxP3-MRBP spread after 2020. MRBP, macrolide-resistant Bordetella pertussis; MT, multilocus variable-number tandem-repeat analysis type.

Figure 3. Changing macrolide resistance of circulating Bordetella pertussis strains, Shanghai, China, 2016–2022. A) ptxP3-strains showed very high resistance to macrolides after 2020. Resistance to macrolides was different in non-MT28 (0%) and MT28 (100%) isolates. B) Percentages of macrolide-sensitive BP, ptxP1-MRBP, and ptxP3-MRBP before and after 2020 show that ptxP1-MRBP strain was prevalent before 2020 but predominately ptxP3-MRBP spread after 2020. MRBP, macrolide-resistant Bordetella pertussis; MT, multilocus variable-number tandem-repeat analysis type.

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Main Article

1These first authors contributed equally to this article.

Page created: November 19, 2023
Page updated: December 20, 2023
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