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Volume 30, Number 1—January 2024
Research

Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016–2022

Pan Fu1Comments to Author , Jinlan Zhou1, Chao Yang, Yaxier Nijiati, Lijun Zhou, Gangfen Yan, Guoping Lu, Xiaowen ZhaiComments to Author , and Chuanqing WangComments to Author 
Author affiliations: National Children's Medical Center, Shanghai, China (P. Fu, J. Zhou, Y. Nijiati, L. Zhou, G. Yan, G. Lu, X. Zhai, C. Wang); Chinese Academy of Sciences, Shanghai (C. Yang)

Main Article

Table

Antimicrobial-resistance profiles and virulence genotypes of 283 Bordetella pertussis isolates, Shanghai, China, 2016–2022*

Antibiotic MIC, μg/mL Total, no (%) Frequency of genotype profiles, no (%)
ptxP1/prn1/fhaB3 non-MT28, n = 141 ptxP3/prn2/fhaB1 non-MT28,† n = 68 ptxP3/prn2/fhaB1 MT28,‡ n = 74
Erythromycin Resistant, >256 205 (72.4) 137 (97.2) 0 68 (91.9)
Sensitive, <0.064
 78 (27.6)
 4 (2.8)
 68 (100)
 6 (8.1)
Azithromycin Resistant, 128 to >256 205 (72.4) 137 (97.2) 0 68 (91.9)
Sensitive, <0.064
 78 (27.6)
 4 (2.8)
 68 (100)
 6 (8.1)
Clarithromycin Resistant, 128 to >256 205 (72.4) 137 (97.2) 0 68 (91.9)
Sensitive, <0.064
 78 (27.6)
 4 (2.8)
 68 (100)
 6 (8.1)
Sulfamethoxazole/ trimethoprim Resistant, >32 0 0 0 0
Sensitive, 0.064 to <0.008 283 (100) 141 (100) 68 (100) 74 (100)

*MT, multilocus variable-number tandem-repeat analysis type. †Includes 1 MT27-ptxP3/prn3/ptxC2 strain. ‡Includes 1 MT28-ptxP3/prn9/fhaB1 strain.

Main Article

1These first authors contributed equally to this article.

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