*TB–COVID-19 co-infected patients had TB and COVID-19 diagnoses within 120 d of each other, whereby >1 of the diseases was diagnosed in 2020. Included California jurisdictions were Alameda, Los Angeles, Orange, Sacramento, San Diego, and Santa Clara Counties. Values are no. (%) except where indicated. Bold text indicates statistical significance (p<0.05). ICU, intensive care unit; NAAT, nucleic acid amplification test; TB, tuberculosis. †Diagnostic delay was defined as >30 d between TB symptom onset and first care visit for TB. ‡Extrapulmonary-only cases not included. §The Healthy Places Index combines 25 community characteristics, such as access to healthcare, housing, education, and more, into a single indexed score; 1st quartile is the least advantaged score. ¶Work that must be done in person and in which the worker interacts with other workers or the public. #Disseminated TB is defined as meningeal, miliary, positive acid-fast bacilli blood culture, or both pulmonary and extrapulmonary TB. **Based on phylogenetic analysis (<5 single-nucleotide polymorphisms) and timing (<3 y) or epidemiologic link. ††California 7-d average incidence of new COVID-19 cases >15 cases per 100,000 population.