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Highly Pathogenic Avian Influenza A Virus in Wild Migratory Birds, Qinghai Lake, China, 2022
Xiaoqing Zhang
1, Jiaying Wu
1, Yanhai Wang, Mengchan Hao, Haizhou Liu, Sanling Fan, Juan Li, Jianqing Sun, Yubang He, Yuan Zhang, and Jianjun Chen
Author affiliations: Wuhan Institute of Virology, Wuhan, China (X. Zhang, J. Wu, Y. Wang, M. Hao, H. Liu, S. Fan, Y. Zhang, J. Chen); University of Chinese Academy Sciences, Beijing, China (X. Zhang, J. Wu, Y. Wang, M. Hao, S. Fan); Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China (J. Li); Qinghai Lake National Nature Reserve, Qinghai, China (J. Sun, Y. He)
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Figure 4
![Mouse models of replication and pathogenicity of highly pathogenic H5 avian influenza viruses isolated from wild birds at Qinghai Lake, China. Each group of mice was inoculated intranasally at a dose of 106 EID50 of H5N1 (3 strains), H5N8, and H5N6 viruses. Mice in the control group were inoculated with PBS. A) Kaplan–Meier survival curve. B) Organ viral titers determined at 3 days postinoculation by measuring EID50 in organ tissue from infected mice. Three mice from each group were euthanized for organ tissue collection. EID50, 50% egg infectious dose; PBS, phosphate-buffered saline.](/eid/images/24-0460-F4.jpg)
Figure 4. Mouse models of replication and pathogenicity of highly pathogenic H5 avian influenza viruses isolated from wild birds at Qinghai Lake, China. Each group of mice was inoculated intranasally at a dose of 106 EID50 of H5N1 (3 strains), H5N8, and H5N6 viruses. Mice in the control group were inoculated with PBS. A) Kaplan–Meier survival curve. B) Organ viral titers determined at 3 days postinoculation by measuring EID50 in organ tissue from infected mice. Three mice from each group were euthanized for organ tissue collection. EID50, 50% egg infectious dose; PBS, phosphate-buffered saline.
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