Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 30, Number 10—October 2024
Dispatch

Circovirus Hepatitis in Immunocompromised Patient, Switzerland

Baptiste Hamelin1, Philippe Pérot1, Ian Pichler1, Jasmin D. Haslbauer, David Hardy, David Hing, Sarra Loulizi, Béatrice Regnault, Anouk Pieters, Ingmar Heijnen, Caroline Berkemeier, Maria Mancuso, Verena Kufner, Niels Willi, Anne Jamet, Nolwenn Dheilly, Marc Eloit, Mike Recher, Michael Huber2, and Kirsten D. Mertz2Comments to Author 
Author affiliations: Cantonal Hospital Baselland, Liestal, Switzerland (B. Hamelin, M. Mancuso, N. Willi, K.D. Mertz); University Hospital Basel, Basel, Switzerland (B. Hamelin, J.D. Haslbauer, I. Heijnen, C. Berkemeier, M. Mancuso, N. Willi, M. Recher, K.D. Mertz); Institut Pasteur, Paris, France (P. Pérot, D. Hardy, D. Hing, S. Loulizi, B. Regnault, N. Dheilly, M. Eloit); University of Zurich, Zurich, Switzerland (I. Pichler, V. Kufner, M. Huber); University of Basel Department of Biomedicine, Basel (A. Pieters, M. Recher, K.D. Mertz); Assistance Publique–Hôpitaux de Paris Centre Université de Paris Cité Necker-Enfants Malades Hospital, Paris (A. Jamet)

Main Article

Figure 2

Phylogenetic analysis of the circovirus isolate from a patient with hepatitis of unknown origin, Switzerland (HCirV-1-CH). Capsid protein sequences representative of human and animal circovirus strains are shown. We aligned sequences by using MAFFT (https://mafft.cbrc.jp/alignment/software) under the L-INS-I parameter and performed maximum-likelihood phylogenetic reconstruction through the IQ-Tree portal (http://www.iqtree.org). Red indicates HCirV-1-FR, HCirV-1-CH, and HuCV2 sequences. Tree scale indicates the number of amino acid substitutions per site. Display range for bootstraps is 0.5–1.0. GenBank accession numbers are provided. HCirV-1-CH, human circovirus 1 from patient in Switzerland; HCirV-1-FR, published human circovirus 1 genome from France; HuCV2, human circovirus sequence detected in injection drug users in China (10); PCV, porcine circovirus.

Figure 2. Phylogenetic analysis of the circovirus isolate from a patient with hepatitis of unknown origin, Switzerland (HCirV-1-CH). Capsid protein sequences representative of human and animal circovirus strains are shown. We aligned sequences by using MAFFT (https://mafft.cbrc.jp/alignment/software) under the L-INS-I parameter and performed maximum-likelihood phylogenetic reconstruction through the IQ-Tree portal (http://www.iqtree.org). Red indicates HCirV-1-FR, HCirV-1-CH, and HuCV2 sequences. Tree scale indicates the number of amino acid substitutions per site. Display range for bootstraps is 0.5–1.0. GenBank accession numbers are provided. HCirV-1-CH, human circovirus 1 from patient in Switzerland; HCirV-1-FR, published human circovirus 1 genome from France; HuCV2, human circovirus sequence detected in injection drug users in China (10); PCV, porcine circovirus.

Main Article

References
  1. Opriessnig  T, Xiao  CT, Mueller  NJ, Denner  J. Emergence of novel circoviruses in humans and pigs and their possible importance for xenotransplantation and blood transfusions. Xenotransplantation. 2024;31:e12842. DOIPubMedGoogle Scholar
  2. Kroeger  M, Temeeyasen  G, Piñeyro  PE. Five years of porcine circovirus 3: What have we learned about the clinical disease, immune pathogenesis, and diagnosis. Virus Res. 2022;314:198764. DOIPubMedGoogle Scholar
  3. Niu  G, Chen  S, Li  X, Zhang  L, Ren  L. Advances in crosstalk between porcine circoviruses and host. Viruses. 2022;14:1419. DOIPubMedGoogle Scholar
  4. Rosell  C, Segalés  J, Domingo  M. Hepatitis and staging of hepatic damage in pigs naturally infected with porcine circovirus type 2. Vet Pathol. 2000;37:687–92. DOIPubMedGoogle Scholar
  5. Pérot  P, Fourgeaud  J, Rouzaud  C, Regnault  B, Da Rocha  N, Fontaine  H, et al. Circovirus hepatitis infection in heart-lung transplant patient, France. Emerg Infect Dis. 2023;29:286–93. DOIPubMedGoogle Scholar
  6. Nienhold  R, Mensah  N, Frank  A, Graber  A, Koike  J, Schwab  N, et al. Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics. Front Cell Infect Microbiol. 2022;12:968135. DOIPubMedGoogle Scholar
  7. Fourgeaud  J, Regnault  B, Ok  V, Da Rocha  N, Sitterlé  É, Mekouar  M, et al. Performance of clinical metagenomics in France: a prospective observational study. Lancet Microbe. 2024;5:e52–61. DOIPubMedGoogle Scholar
  8. Chiu  CY, Miller  SA. Clinical metagenomics. Nat Rev Genet. 2019;20:341–55. DOIPubMedGoogle Scholar
  9. Pérot  P, Bigot  T, Temmam  S, Regnault  B, Eloit  M. Microseek: a protein-based metagenomic pipeline for virus diagnostic and discovery. Viruses. 2022;14:1990. DOIPubMedGoogle Scholar
  10. Li  Y, Zhang  P, Ye  M, Tian  RR, Li  N, Cao  L, et al. Novel circovirus in blood from intravenous drug users, Yunnan, China. Emerg Infect Dis. 2023;29:1015–9. DOIPubMedGoogle Scholar
  11. Pérot  P, Da Rocha  N, Farcet  MR, Kreil  TR, Eloit  M. Human Circovirus is not detected in plasma pools for fractionation. Transfusion. 2024;64:16–8. DOIPubMedGoogle Scholar
  12. Turlewicz-Podbielska  H, Augustyniak  A, Pomorska-Mól  M. Novel porcine circoviruses in view of lessons learned from porcine circovirus type 2-epidemiology and threat to pigs and other species. Viruses. 2022;14:261. DOIPubMedGoogle Scholar

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: August 13, 2024
Page updated: September 03, 2024
Page reviewed: September 03, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external