Clinical and Genomic Epidemiology of Coxsackievirus A21 and Enterovirus D68 in Homeless Shelters, King County, Washington, USA, 2019–2021
Sarah N. Cox
, Amanda M. Casto, Nicholas M. Franko, Eric J. Chow, Peter D. Han, Luis Gamboa, Brian Pfau, Hong Xie, Kevin Kong, Jaydee Sereewit, Melissa A. Rolfes, Emily Mosites, Timothy M. Uyeki, Alexander L. Greninger, Marco Carone, M. Mia Shim, Trevor Bedford, Jay Shendure, Michael Boeckh, Janet A. Englund, Lea M. Starita, Pavitra Roychoudhury, and Helen Y. Chu
Author affiliation: University of Washington, Seattle, Washington, USA (S.N. Cox, A.M. Casto, N.M. Franko, E.J. Chow, H. Xie, K. Kong, J. Sereewit, A.L. Greninger, M.M. Shim, T. Bedford, J. Shendure, M. Boeckh, J.A. Englund, L.M. Starita, P. Roychoudhury, H.Y. Chu); Public Health Seattle and King County, Seattle (E.J. Chow, M.M. Shim); Brotman Baty Institute for Precision Medicine, Seattle (P.D. Han, L. Gamboa, B. Pfau, T. Bedford, J. Shendure, L.M. Starita); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.A. Rolfes, E. Mosites, T.M. Uyeki); Fred Hutchinson Cancer Research Center, Seattle (A.L. Greninger, M. Carone, T. Bedford, M. Boeckh, P. Roychoudhury); Howard Hughes Medical Institute, Seattle (T. Bedford, J. Shendure); Seattle Children’s Research Institute, Seattle (J.A. Englund)
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Figure 5
Figure 5. Phylogenetic trees of sequenced coxsackievirus A21 specimens of homeless shelter residents, King County, Washington, USA, October 2019–February 2020. A) Tree containing all shelter coxsackievirus A21 and all coxsackievirus A21 genomes deposited in GenBank. Tips representing study specimens are colored according to shelter. Light gray tips represent coxsackievirus A21 genomes downloaded from GenBank. The x-axis represents number of nucleotide changes in the genome relative to a coxsackievirus A21 reference genome (GenBank accession no. AF465515.1). B) Tree containing all shelter coxsackievirus A21 genomes. Internal nodes with >90% bootstrap support are labeled on tree. C) Tree containing all shelter coxsackievirus A21 genomes with x-axis corresponding to specimen collection date.
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