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Volume 30, Supplement—October 2024
SUPPLEMENT ISSUE
Articles

Metagenomic Nanopore Sequencing of Tickborne Pathogens, Mongolia

Koray Ergunay1Comments to Author , Bazartseren Boldbaatar1, Brian P. Bourke, Laura Caicedo-Quiroga, Cynthia L. Tucker, Andrew G. Letizia, Nora G. Cleary, Abigail G. Lilak, Guugandaa Nyamdavaa, Sharav Tumenjargal, Michael E. von Fricken2, and Yvonne-Marie Linton2
Author affiliation: Walter Reed Biosystematics Unit, Smithsonian Institution Museum Support Center, Suitland, Maryland, USA (K. Ergunay, B.P. Bourke, L. Caicedo-Quiroga, C.L. Tucker, Y-M. Linton); Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (K. Ergunay, B.P. Bourke, L. Caicedo-Quiroga, C.L. Tucker, Y-M. Linton); Smithsonian Institution National Museum of Natural History, Washington, DC, USA (K. Ergunay, B.P. Bourke, L. Caicedo-Quiroga, C.L. Tucker, Y-M. Linton); Mongolian University of Life Sciences School of Veterinary Medicine, Ulaanbaatar, Mongolia (B. Boldbaatar, G. Nyamdavaa, S. Tumenjargal); Naval Medical Research Unit INDO PACIFIC, Sembawang, Singapore (A.G. Letizia); University of Florida College of Public Health and Health Professions, Gainesville, Florida, USA (N.G. Cleary, A.G. Lilak, M.E. von Fricken)

Main Article

Table 2

Amino acid substitutions in the Alongshan virus VP1a, VP1b, and nuORF proteins compared with ALSV-Mongolia-b52 in a metagenomic nanopore sequencing study of tickborne pathogens, Mongolia*

Virus protein Amino acid position Ixodes ricinus tick group Ixodes persulcatus tick group
 ALSV-Mongolia-b52
Europe subgroup Asia subgroup
VP1a 8 Ala Ala Thr Thr
72 Val Ala Ala Ala
115 Ala Val Val Val
135 Val Lys Lys Lys
138 Pro Ser Ser Ser
153 Lys Arg Arg Arg
210 Gly Gly Ser Ser
216 Thr Ala Ala Ala
321 Val Val Thr Thr
460 Thr Met Thr Thr
472 Arg His His His
476
 Arg
 Arg
 Gln
 Gly
VP1b 58 Met Met Leu Leu
112 Ile Ile Val Val
127 Lys Lys Arg Arg
135 Ser Ser Gly Gly
216
 Val
 Ile
 Ile
 Ile
nuORF 4 Lys Lys Gly Gly
15 Asp Asp Asn Asn
132 Thr Ala Thr Thr

*ALSV, Alongshan virus; nuORF, novel upstream open reading frame; VP, virus capsid protein.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: October 24, 2024
Page updated: November 11, 2024
Page reviewed: November 11, 2024
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