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Volume 30, Supplement—October 2024
SUPPLEMENT ISSUE
Articles

Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance

Adriana Le VanComments to Author , Nazia Rahman, Reuel Sandy, Nelson Dozier, Hunter J. Smith, Melissa J. Martin, Katelyn V. Bartlett, Krit Harncharoenkul, Anna Nanava, Tamar Akhvlediani, Paul Rios, Supriya D. Mehta, Walter Agingu, Denis K. Byarugaba, Fred Wabwire-Mangen, Hannah Kibuuka, Bernard Erima, Hope O. Kabatasi, Naiki Attram, Dutsadee Peerapongpaisarn, Wilawan Oransathit, Wirote Oransathit, Umaporn Suksawad, Woradee Lurchachaiwong, Somchai Sriplienchan, Nonlawat Boonyalai, Maneerat Somsri, Nithinart Chaitaveep, Ann Jerse, and Eric Garges
Author affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA (A. Le Van, R. Sandy); Uniformed Services University, Bethesda (A. Le Van, R. Sandy, N. Dozier, A. Jerse, E. Garges); Cherokee Nation Strategic Programs, Tulsa, Oklahoma, USA (N. Rahman); Global Emerging Infections Surveillance Branch, Armed Forces Health Surveillance Division, Silver Spring, Maryland, USA (N. Rahman, H.J. Smith); Multidrug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring (M.J. Martin, K.V. Bartlett); Walter Reed Army Institute of Research, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand (K. Harncharoenkul, D. Peerapongpaisarn, Wilawan Oransathit, Wirote Oransathit, U. Suksawad, W. Lurchachaiwong, S. Sriplienchan, N. Boonyalai, M. Somsri, N. Chaitaveep); Walter Reed Army Institute of Research Europe-Middle East, Tbilisi, Georgia (A. Nanava, T. Akhvlediani); US Naval Medical Research Unit SOUTH, Lima, Peru (P. Rios); Rush University College of Medicine, Chicago, Illinois, USA (S.D. Mehta); Walter Reed Army Institute of Research-Africa, Kisumu, Kenya (W. Agingu); Makerere University Walter Reed Project, Kampala, Uganda (D.K. Byarugaba); Makerere University College of Veterinary Medicine, Kampala (D.K. Byarugaba, F. Wabwire-Mangen, H. Kibuuka, B. Erima, H.O. Kabatasi); US Naval Medical Research Unit EURAFCENT, Accra, Ghana (N. Attram); Walter Reed Army Institute of Research-Africa, Nairobi, Kenya (E. Garges)

Main Article

Table 2

Presence of antimicrobial-resistant genetic determinants in study of common patterns and unique threats in antimicrobial resistance as demonstrated by global gonococcal surveillance*

Region No. (%) isolates
Tetracycline resistance
 Benzylpenicillin resistance
 Ciprofloxacin resistance
 Azithromycin resistance
 Cefixime and ceftriaxone resistance
V57 tetM β-lactams ponAL421P gyrA parC mtrD Mtr penA
Thailand, n = 516
 506 (98)
 449 (87)
blaTEM-1, 327 (63.4); blaTEM-135, 77 (15)
80 (15.5)
S91, D95, 318 (61.6)
 D86, 217 (42); S87, 218 (42.2); E91, 21 (4); S88, 8 (1.5)
MtrD S821A K823E, 7 (1.35)
Internal stop codon, 27 (5.3)
 I312M V316T
G545S, 2 (0.38)
Ghana, n = 19
 19 (100)
 15 (79)
blaTEM-1, 13 (68.4)
 16 (84.2)
S91, D95, 17 (89.5)
 D86, 3 (17.6); S87, 12 (70.6); E91, 1 (5.9)
0
G45D, 7 (36.8)
 I312M V316T G545S, 1 (5.26)
Peru, n = 208
 208 (100)
 87 (41.8)
blaTEM-1, 111 (53.3); blaTEM-135, 13 (6.25); blaTEM-22, 1 (0.48)
120 (57.6)
S91; D95, 188 (90.3)
 D86, 52 (28); S87, 46 (24.7)
MtrD mosaic 2, MtrR mosaic 2, 2 (0.96)
G45D, 21 (10)
 I312M V316T G545S, 17 (8.17)
Nairobi, Kenya, n = 27
 27 (100)
 23 (85.2)
blaTEM-1, 22, 81.5)
 12 (44.4)
S91, D95, 21 (77.7)
 D86, 1 (4.76)
0
0
 0
Kisumu, Kenya, n = 110
 110 (100)
 99 (90)
blaTEM-1, 32 (29); blaTEM-135, 3 (2.72); blaTEM-239, 5 (4.54)
 66 (60)
S91, D95, 106 (96.3)
 D86, 10 (9); S87, 9 (8.2); E91, 65 (59)
23s rDNA A2045G, 2 (1.8)
A39, 84 (76.5); G45, 2 (1.8); D79, 11 (10); M197, 1 (0.9)
A501, F504, A516 N512, 4 (3.6)
Uganda, n = 10
 10 (100)
 10 (100)
blaTEM-1, 8 (80); blaTEM-135, 1 (10); blaTEM-239, 1 (10)
 5 (55)
S91, D95, 10 (100)
 D86, 4 (40); S87, 2 (20); E91, 4 (40)
0
A39, 8 (80); D79, 2 (20)
 F504, 10 (100); A516, 10 (100)
Georgia, n = 72
 47 (65.3)
 14 (19.4)
blaTEM-1, 11 (15.3)
 40 (55.5)
S91, D95, 41 (57)
 D86, 12 (19.5); S87, 31 (75.6); E91, 12 (29.3)
MtrD mosaic 2, MtrR mosaic 2, 2 (2.7); MtrD S821A K823E, 5 (6.9)
A39, 28 (38.9); G45, 6 (8.3); D79, 14 (19.4); M197, 2 (2.7)
 I312M V316T G545S, 9 (12.5%)
Total, N = 962 928 (96.4) 697 (72.5) blaTEM-1, 524 (54.5); blaTEM-135, 94 (9.77); blaTEM-239, 6 (0.62); blaTEM-22, 1 (0.10) 339 (35.2) S91, D95, 701 (72.9) D86, 299 (31); S87, 318 (33); E91, 103 (10.7) A39, 641 (66.6);
G45D, 36 (3.74)

*Percentages calculated on total number of Neisseria gonorrhoeae isolates confirmed for the country.

Main Article

Page created: October 30, 2024
Page updated: November 11, 2024
Page reviewed: November 11, 2024
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