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Volume 30, Number 2—February 2024
Research

Piscichuvirus-Associated Severe Meningoencephalomyelitis in Aquatic Turtles, United States, 2009–2021

Weerapong Laovechprasit, Kelsey T. Young, Brian A. Stacy, Steven B. Tillis, Robert J. Ossiboff, Jordan A. Vann, Kuttichantran Subramaniam, Dalen W. Agnew, Elizabeth W. Howerth, Jian Zhang, Shayna Whitaker, Alicia Walker, Andrew M. Orgill, Lyndsey N. Howell, Donna J. Shaver, Kyle Donnelly, Allen M. Foley, and James B. StantonComments to Author 
Author affiliations: University of Georgia, Athens, Georgia, USA (W. Laovechprasit, K.T. Young, E.W. Howerth, J. Zhang, J.B. Stanton); National Oceanic and Atmospheric Administration, Pascagoula, Mississippi, USA (B.A. Stacy, L.N. Howell); University of Florida, Gainesville, Florida, USA (S.B. Tillis, R.J. Ossiboff, J.A. Vann, K. Subramaniam); Michigan State University, Lansing, Michigan, USA (D.W. Agnew); Amos Rehabilitation Keep at University of Texas Marine Science Institute, Port Aransas, Texas, USA (S. Whitaker, A. Walker, A.M. Orgill); National Park Service at Padre Island National Seashore, Corpus Christi, Texas, USA (D.J. Shaver); Brevard Zoo and Sea Turtle Healing Center, Melbourne, Florida, USA (K. Donnelly); Florida Fish and Wildlife Conservation Commission, Jacksonville, Florida, USA (A.M. Foley)

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Figure 2

Representative tissue sections from the central nervous system of an alligator snapping turtle (Macrochelys sp.) with meningoencephalomyelitis, United States, 2009. A) Cerebellum; lymphoplasmacytic perivascular cuffs (asterisk) and infiltrates are widely disseminated in the gray matter and the adjacent leptomeninges. Hematoxylin and eosin stain. B) Replicate section of the same tissue shown in panel A. There is strong in situ hybridization signal (red) against freshwater turtle neural virus 1 (FTuNV1) in the cytoplasm of small neurons and glial cells throughout the gray matter and associated with the lymphoplasmacytic infiltrates. Hematoxylin counterstain. C) Optic tectum; several neurons have central chromatolysis (arrows). Hematoxylin and eosin stain. D) A replicate section of the tissue shown in panel C. Intense in situ hybridization signal (red) against FTuNV1 was within the neuronal and glial cytoplasm. Scale bars indicate 50 µm.

Figure 2. Representative tissue sections from the central nervous system of an alligator snapping turtle (Macrochelys sp.) with meningoencephalomyelitis, United States, 2009. A) Cerebellum; lymphoplasmacytic perivascular cuffs (asterisk) and infiltrates are widely disseminated in the gray matter and the adjacent leptomeninges. Hematoxylin and eosin stain. B) Replicate section of the same tissue shown in panel A. There is strong in situ hybridization signal (red) against freshwater turtle neural virus 1 (FTuNV1) in the cytoplasm of small neurons and glial cells throughout the gray matter and associated with the lymphoplasmacytic infiltrates. Hematoxylin counterstain. C) Optic tectum; several neurons have central chromatolysis (arrows). Hematoxylin and eosin stain. D) A replicate section of the tissue shown in panel C. Intense in situ hybridization signal (red) against FTuNV1 was within the neuronal and glial cytoplasm. Scale bars indicate 50 µm.

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Page created: December 21, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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