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Volume 30, Number 2—February 2024
Dispatch

Critically Ill Patients with Visceral Nocardia Infection, France and Belgium, 2004–2023

Lucas KhellafComments to Author , Virginie Lemiale, Maxens Decavèle, Marc Pineton de Chambrun, Alexandra Beurton, Toufik Kamel, Anabelle Stoclin, Djamel Mokart, Fabrice Bruneel, Clara Vigneron, Achille Kouatchet, Benoît Henry, Jean-Pierre Quenot, Grégoire Jolly, Nahema Issa, Matthieu Bellal, Julien Poissy, Claire Pichereau, Julien Schmidt, Nathalie Layios, Maxime Gaillet, Elie Azoulay, and Adrien Joseph
Author affiliations: Saint-Louis Teaching Hospital, Public Assistance Hospitals of Paris (APHP), Paris, France (L. Khellaf, V. Lemiale, E. Azoulay, A. Joseph); Pitié-Salpétière Teaching Hospital, APHP, Paris (M. Decavèle, M. Pineton de Chambrun); Hôpital Tenon, Groupe Hospitalo-Universitaire Sorbonne University, APHP, Paris (A. Beurton); Centre Hospitalier Régional d’Orléans, Orléans, France (T. Kamel); Institut Gustave Roussy, Villejuif, France (A. Stoclin); Institut Paoli Calmettes, Marseille, France (D. Mokart); Centre Hospitalier de Versailles, Hôpital André Mignot, Le Chesnay, France (F. Bruneel); Cochin Teaching Hospital, APHP, Paris (C. Vigneron); Centre Hospitalier Universitaire d’Angers, Angers, France (A. Kouatchet); Hôpital Bicêtre, APHP, France (B. Henry); Dijon Bourgogne University Hospital, Dijon, France (J.-P. Quenot); Rouen University Hospital, Rouen, France (G. Jolly); Saint-André Hospital, Bordeaux, France (N. Issa); University Hospital of Caen, Caen, France (M. Bellal); Hôpitaux Universitaires de Strasbourg, Strasbourg, France (J. Poissy); Centre Hospitalier Intercommunal de Poissy Saint Germain, Poissy, France (C. Pichereau); Avicennes Hospital, APHP, Ile de France, France (J. Schmidt); University Hospital of Liege, Liege, Belgium (N. Layios); Lyon University Hospital, Lyon, France (M. Gaillet)

Main Article

Table 1

Baseline characteristics of patients in study of critically ill patients with visceral Nocardia infection, France and Belgium, 2004–2023*

Baseline characteristics Nocardiosis cases, n = 50
Age, y, median (IQR)
 59 (47–67)
Sex
M 39 (78)
F
 11 (22)
Charlson score, median (IQR) 4 (3–7)
Cardiovascular risk factors, median (IQR)
 2 (1–3)
Immunosuppression 46 (92)
Corticosteroids at admission 34 (68)
5–10 mg/d 5 (10)
>10 mg/d 29 (58)
Tacrolimus treatment 16 (32)
Mycophenolate mofetil treatment 12 (24)
Other conventional immunosuppressive drugs†
 5 (10)
Organ transplantation 18 (36)
Kidney 12 (24)
Heart 4 (8)
Liver 1 (2)
Lung
 1 (2)
Systemic autoimmune disease‡
 12 (24)
Hematologic malignancies 10 20)
Aggressive B cell lymphoma 6 (12)
Acute lymphoid leukemia 3 (6)
Acute myeloid leukemia
 1 (2)
No. lymphocytes/mm3, median (IQR) 552 (287–1,210)
Gamma globulin, g/L, median (IQR) 6 (4–10)
Trimethoprim/sulfamethoxazole prophylaxis 12 (24)

*Values are no. (%) except as indicated. IQR, interquartile range. †Azathioprine, n = 4 (8%); methotrexate, n = 1 (2%). ‡Connective tissue disease, n = 2; glomerulonephritis, n = 1; periarteritis nodos, n = 1; bullous pemphigoid, n = 1; Evans syndrome, n = 1; IgA vasculitis, n = 1; type 1 diabetes, n = 1; myasthenia gravis, n = 1; sarcoidosis, n = 1; chronic inflammatory demyelinating polyradiculoneuropathy, n = 1; inflammatory bowel disease, n = 1.

Main Article

Page created: December 21, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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