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Volume 30, Number 3—March 2024
CME ACTIVITY - Research

Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Paulo R.L. MachadoComments to Author , Alexsandro Lago, Thiago M. Cardoso, Andréa Magalhaes, Lucas P. Carvalho, Tainã Lago, Augusto M. Carvalho, Rúbia Costa, and Edgar M. Carvalho
Author affiliations: Federal University of Bahia, Salvador, Brazil (P.R.L. Machado, A. Lago, A. Magalhaes, L.P. Carvalho, T. Lago, R. Costa, E.M. Carvalho); National Institute of Science and Technology of Tropical Diseases (INCT-DT), Brasília, Brazil (P.R.L. Machado, L.P. Carvalho, A.M. Carvalho, E.M. Carvalho); Fiocruz, Salvador (T.M. Cardoso, A. Magalhaes, L.P. Carvalho, A.M. Carvalho, R. Costa, E.M. Carvalho)

Main Article

Table 1

Demographic, clinical, laboratory, and therapeutic characteristics of DL and CL patients in study of leishmaniasis immune response and clinical and therapeutic outcomes, Corte de Pedra Health Post, Brazil, 2016–2019*

Characteristic DL, n = 101 CL, n = 101 p value
Age, y
 39.5 + 14.8
 32 + 13.3
 0.0002†
Sex, no. (%) patients.
M 88 (87) 69 (68) 0.04‡
F
 13 (13)
 23 (32)
 0.04‡
Duration of disease until diagnosis, d
 52.7 + 2.7
 41 + 1.7
 0.0003†
No. lesions 113.6 + 210 1.4 + 0.7 <0.0001†
Biggest lesion size, mm2
 775.6 + 2,190
 392.7 + 283.4
 NS
Lymphadenopathy, no. positive/no. tested (%) 47/93 (50.5) 61/101 (60.4) NS
LST size, mm2 102.3 + 96.5 213.6 + 126.9 0.0001†
LST , no. positive/no. tested (%) 64/97 (66) 101/101 (100) 0.0001‡
PCR. no. positive/no. tested (%) 84/91 (92) 101/101 (100) NS
Cure rate, no. cured/no. treated (%)§ 34/78 (44)¶ 44/101 (60) NS
Healing time, d§ 177 + 19.6 110.8 + 7.7 0.001†

*Values are mean + SD unless otherwise indicated. CL, cutaneous leishmaniasis; DL, disseminated leishmaniasis; LST, Leishmania skin test, NS, not significant. †By unpaired t-test. ‡By Fisher exact test. §After 1 standard course of meglumine antimoniate (20 mg/kg/d) for 20 d (CL) or 30 d (DL). ¶Six patients had no outcome data, irregular use, or discontinuation.

Main Article

Page created: January 26, 2024
Page updated: February 23, 2024
Page reviewed: February 23, 2024
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