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Volume 30, Number 3—March 2024
CME ACTIVITY - Research

Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Paulo R.L. MachadoComments to Author , Alexsandro Lago, Thiago M. Cardoso, Andréa Magalhaes, Lucas P. Carvalho, Tainã Lago, Augusto M. Carvalho, Rúbia Costa, and Edgar M. Carvalho
Author affiliations: Federal University of Bahia, Salvador, Brazil (P.R.L. Machado, A. Lago, A. Magalhaes, L.P. Carvalho, T. Lago, R. Costa, E.M. Carvalho); National Institute of Science and Technology of Tropical Diseases (INCT-DT), Brasília, Brazil (P.R.L. Machado, L.P. Carvalho, A.M. Carvalho, E.M. Carvalho); Fiocruz, Salvador (T.M. Cardoso, A. Magalhaes, L.P. Carvalho, A.M. Carvalho, R. Costa, E.M. Carvalho)

Main Article

Table 3

Clinical profile and response to therapy of disseminated leishmaniasis patients treated with amphotericin b, miltefosine, and miltefosine plus meglumine antimoniate in study of leishmaniasis immune response and clinical and therapeutic outcomes, Corte de Pedra Health Post, Brazil, 2016–2019*

Treatment† Age, y % Men Illness duration, d No. lesions Cure rate on day 90 Healing time
Amphotericin B, n = 9 59 + 5.1 88.8% 54 + 16.9 350 + 489.1 55.5% 137 + 1113
Miltefosine, n = 5 54 + 9.2 100% 54 + 9.2 49 + 18.8 40% 96 + 27.9
Miltefosine + MA, n = 5 57 + 9.3 80% 42 + 7.5 181 + 204.2 100% 53 + 18.3
MA, n = 78 39 + 16.7 84.6% 53 + 6.1 116 + 217.3 44% 177 + 19.6
p value 0.51‡ 0.47§ 0.32¶ 0.26¶ NA 0.01¶

*Values are mean + SD unless otherwise indicated. MA, meglumine antimoniate; NA, not applicable. †The total number of disseminated leishmaniasis cases with therapeutic outcome was 97. We have no follow-up data for 4 patients. ‡By student t-test. §Fisher exact test. ¶Kruskal-Wallis test.

Main Article

Page created: January 26, 2024
Page updated: February 23, 2024
Page reviewed: February 23, 2024
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