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Volume 30, Number 5—May 2024
Research Letter

Detection of OXA-181 Carbapenemase in Shigella flexneri

Ghulam Dhabaan1, Hassan Jamal1, Danielle Ouellette, Sarah Alexander, Karen Arane, Aaron Campigotto, Manal Tadros, and Pierre-Philippe Piché-RenaudComments to Author 
Author affiliations: The Hospital for Sick Children, Toronto, Ontario, Canada (G. Dhabaan, H. Jamal, S. Alexander, K. Arane, A. Campigotto, M. Tadros, P.-P. Piché-Renaud); University of Toronto, Toronto (G. Dhabaan, H. Jamal, S. Alexander, K. Arane, A. Campigotto, M. Tadros, P.-P. Piché-Renaud); King Abdulaziz University, Jeddah, Saudi Arabia (H. Jamal); Western University, London, Ontario (D. Ouellette)

Main Article

Table 1

Antibiotic-susceptibility results using 5 different methodologies for the Shigella flexneri bacteria cultured from an immunocompromised patient, Canada*

Antibiotic BD Phoenix,† mg/L Broth microdilution, mg/L Agar dilution, mg/L CLSI breakpoints for susceptibility, mg/L Kirby–Bauer
disk diffusion, mm
Azithromycin NA NA >32 <8 NA
Ceftriaxone 0.5 0.5 NA <1 28
Ceftazidime 0.5 1 NA <4 30
Ertapenem >1 1 <0.5 <0.5 24
Meropenem 0.5 0.5‡ <0.12 <1 24
Ciprofloxacin 2 >2 NA <0.25 NA
TMP/SMX <0.5 2/38 NA <2/38 NA
Colistin NA NA <0.25 <2§ NA

*CLSI, Clinical and Laboratory Standards Institute; NA, not available; TMP/SMX, trimethoprim/sulfamethoxazole. †Becton Dickinson, https://www.bd.com. ‡Lowest concentration for meropenem on methodology used (Gram negative sensititer panel). §Intermediate susceptibility.

Main Article

1These authors contributed equally to this article.

Page created: March 22, 2024
Page updated: April 24, 2024
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