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Volume 30, Number 6—June 2024
Research

Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru

Qi Tan1, Chuan-Chin Huang1, Mercedes C. Becerra, Roger Calderon, Carmen Contreras, Leonid Lecca, Judith Jimenez, Rosa Yataco, Jerome T. Galea, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, and Megan B. MurrayComments to Author 
Author affiliations: Harvard Medical School, Boston, Massachusetts, USA (Q. Tan, C.-C. Huang, M.C. Becerra, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Partners In Health—Socios En Salud Sucursal Peru, Lima, Peru (R. Calderon, C. Contreras, L. Lecca, J. Jimenez, R. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea); Taipei Veterans General Hospital, Taipei, Taiwan (J.-Y. Feng, S.-W. Pan, Y.-H. Tseng, J.-R. Huang); National Yang Ming Chiao Tung University, Taipei (J.-Y. Feng, S.-W. Pan, Y.-H. Tseng, J.-R. Huang); Harvard T.H. Chan School of Public Health, Boston (M.B. Murray)

Main Article

Table 2

Chest radiograph and symptom screening results and their association with risk for subsequent TB in tuberculin skin test–positive adults, Peru*

Result† No. household contacts No. (%) incident TB cases Univariate analysis
 Multivariate analysis‡
Hazard ratio (95% CI), n = 1,747, events = 52§ p value Hazard ratio (95% CI), n = 1,630, events = 49§ p value
CXR–SX– 1,349 18 (1) Referent Referent
CXR–SX+ 263 7 (3) 2.01 (0.84–4.82) 0.12 2.24 (0.92–5.47) 0.08
CXR+SX– 112 20 (18) 14.64 (7.74–27.67) <0.001 15.62(7.74–31.54) <0.001
CXR+SX+ 23 7 (30) 26.85 (11.21–64.31) <0.001 26.50 (9.98–70.36) <0.001

*In both analyses, n indicates number of analyzed participants and event indicates number of participants in whom incident TB developed. CXR–, unremarkable chest radiograph, CXR+, abnormal chest radiograph; SX–, no symptoms; SX+, symptoms; TB, tuberculosis. †Household contacts were categorized into 4 groups by screening results: CXR–SX–, n = 1,349; CXR–SX+, n = 263; CXR+SX–, n = 112; CXR+SX+, n = 23. Symptoms were defined as any of the following: cough>14 d, cough with blood or phlegm, fever, shortness of breath, night sweats. Abnormal chest radiograph was defined as a radiograph with any intra-thorax abnormalities compatible with TB. ‡Adjusted for age, sex, alcohol use, tobacco use, diabetes, hypertension, cardiovascular disease, kidney disease, asthma, previous TB history, and body mass index. HIV-positive participants (n = 4) were excluded.

Main Article

1These authors contributed equally to this article.

Page created: April 19, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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