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Volume 30, Number 8—August 2024
Dispatch
Hepatitis B Virus Reactivation After Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody
Eisuke Adachi1
, Ayako Sedohara1, Kotaro Arizono, Kazuaki Takahashi, Amato Otani, Yoshiaki Kanno, Makoto Saito, Michiko Koga, and Hiroshi Yotsuyanagi
, Ayako Sedohara1, Kotaro Arizono, Kazuaki Takahashi, Amato Otani, Yoshiaki Kanno, Makoto Saito, Michiko Koga, and Hiroshi Yotsuyanagi
Table 3
Results of HBV DNA genome analysis on HBV strain isolated during hepatitis B reactivation in a person with HIV after changing antiretroviral therapy regimen to cabotegravir/rilpivirine*
| Category |
Region |
||||
| S gene |
P gene |
Pre-S1/pre-S2/S |
X gene |
Precore/core |
|
| Position | 155–835 | 2307–3221, 1–1623 | 2854–3221, 1–835 | 1374–1838 | 1814–2458/1901–2458 |
| Size, bp |
681 |
2538 |
1203 |
465 |
645 |
| Mutations | |||||
| Vaccine-escape | E164V | NA | NA | NA | NA |
| Drug-resistant | NA | ND | NA | NA | NA |
| Promoter | NA | NA | NA | NA | ND |
| Other | NA | NA | ND | ND | T1858C,† T1674C† |
*The full length of the HBV isolate was 3,221 bp. HBV, hepatitis B virus; NA, not applicable; ND, not detected. †These mutations are typically observed in genotype A2.
1These first authors contributed equally to this article.
Page created: June 28, 2024
Page updated: July 19, 2024
Page reviewed: July 19, 2024
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