Volume 31, Number 1—January 2025
Dispatch
Invasive Group B Streptococcus Infections Caused by Hypervirulent Clone of S. agalactiae Sequence Type 283, Hong Kong, China, 20211
Table
Characteristic | Total, n = 95 | Non-ST283, n = 38 | ST283, n = 57 | p value† |
---|---|---|---|---|
Age, y | ||||
Mean ± SD | 66.7 ± 17.8 | 67.2 ± 24.3 | 66.4 ± 12 | 0.7 |
Range |
0–96 |
0–96 |
31–90 |
|
Age group | ||||
<65 | 39 | 13 | 26 | 0.19 |
>65 |
56 |
25 |
31 |
|
Sex | ||||
M | 50 | 20 | 30 | 0.58 |
F |
45 |
18 |
27 |
|
Length of hospital stay, d | ||||
Average | 24.4 | 25.7 | 23.6 | 0.76 |
Range |
1–202 |
1–202 |
1–100 |
|
Median (IQR) C-reactive protein, mg/dL | NA | 7.2 (2.7–11.9) | 18.3 (11.6–24.9) | <0.001 |
Median (IQR) Urea, mmol/L | NA | 7.45 (4.9–11.3) | 6.7 (4.8–9.1) | 0.03 |
Death outcome during admission |
8 |
3 |
5 |
1 |
Specimen | ||||
Blood | 93 | 38 | 55 | 0.5 |
Other‡ |
2 |
0 |
2 |
NA |
Clinical diagnoses/symptoms§ | ||||
Septicemia/sepsis | 43 | 18 | 26 | 0.52 |
Joint infection | 18 | 3 | 15 | 0.02 |
Skin infection | 10 | 6 | 4 | 0.31 |
Meningitis | 7 | 1 | 6 | 0.23 |
Urinary tract infection | 7 | 5 | 2 | 0.31 |
Pneumonia |
6 |
4 |
2 |
0.21 |
Comorbidities§ | ||||
Diabetes mellitus | 11 | 5 | 6 | 0.75 |
History of any tumor/ cancer | 7 | 5 | 2 | 0.11 |
Congestive heart failure | 6 | 2 | 4 | 1 |
Myocardial infarction | 3 | 1 | 2 | 1 |
Cerebrovascular disease | 4 | 1 | 3 | 0.64 |
Moderate to severe renal disease | 3 | 3 | 0 | 0.06 |
Peripheral vascular disease | 2 | 0 | 2 | 0.51 |
Dementia | 2 | 2 | 0 | 0.15 |
Moderate to severe liver disease | 2 | 0 | 2 | 0.51 |
Comorbidity score >2 |
5 |
3 |
2 |
0.64 |
Hospital cluster of cases | ||||
Hong Kong East | 11 | 3 | 8 | 0.52 |
Kowloon Central | 21 | 10 | 11 | 0.46 |
Kowloon East | 17 | 6 | 11 | 0.79 |
Kowloon West | 21 | 8 | 13 | 1 |
New Territories East | 12 | 4 | 8 | 0.76 |
New Territories West |
13 |
7 |
6 |
0.36 |
ST | ||||
283 | 57 | NA | 57 | NA |
1 | 11 | 11 | NA | NA |
17 | 4 | 4 | NA | NA |
890 | 4 | 4 | NA | NA |
12 | 3 | 3 | NA | NA |
Other¶ | 16 | 16 | NA | NA |
*Values are no. patients except as indicated. Boldface indicate significance. NA, not applicable; IQR, interquartile range; ST, sequence type. †p values were calculated by χ2 test or t-test where appropriate. ‡Includes cerebrospinal fluid, joint fluid, and tissue. §A patient can have multiple symptoms and comorbidities. ¶STs isolated from <2 patients, including ST3, ST7, ST10, ST19, ST28, and ST654 (2 isolates/ST) and 1 each of ST24, ST27, ST452, and ST739.
1Preliminary results from this study were presented at the 3rd ISSAD (International Symposium on ‘Streptococcus agalactiae’ Disease); October 16–18, 2023; Rio de Janeiro, Brazil.
2These first authors contributed equally to this article.
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