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Volume 31, Number 11—November 2025

Research Letter

Extensively Drug-Resistant Tuberculosis with Conflicting Resistance Testing Results, Lesotho

Kwonjune J. SeungComments to Author , Meseret Asfaw, Mikanda Kunda, Llang Bridget Maama-Maime, Joalane Makaka, Mabatloung Mofolo, Stephane Mpinda, Melino Ndayizigiye, Shaheed Vally Omar, Prithiv Prasad, Praharshinie Rupasinghe, Chase Yarbrough, and Lawrence Oyewusi
Author affiliation: Brigham and Women’s Hospital, Boston, Massachusetts, USA (K. Seung, C. Yarbrough); Partners In Health, Maseru, Lesotho (M. Asfaw, M. Kunda, J. Makaka, M. Mofolo, S. Mpinda, M. Ndayizigiye, P. Prasad); Government of Lesotho Ministry of Health and Social Welfare, Maseru (L.B. Maama-Maime, L. Oyewusi); National Institute for Communicable Diseases, Johannesburg, South Africa (S.V. Omar); Institute of Tropical Medicine, Antwerp, Belgium (P. Rupasinghe)

Main Article

Figure

Data from patient with extensively drug-resistant tuberculosis with conflicting resistance testing results, Lesotho. A) Treatment regimen of the patient. B–C) Drug-resistance mutations (B) and MICs (C) of Mycobacterium tuberculosis isolates collected from the patient during months 19 and 42 of treatment. Whole-genome sequence analysis for drug resistance was conducted at the South Africa National Institute for Communicable Diseases (Johannesburg, South Africa), and MIC testing with broth microdilution was conducted at the Institute of Tropical Medicine (Antwerp, Belgium).

Figure. Data from patient with extensively drug-resistant tuberculosis with conflicting resistance testing results, Lesotho. A) Treatment regimen of the patient. B–C) Drug-resistance mutations (B) and MICs (C) of Mycobacterium tuberculosis isolates collected from the patient during months 19 and 42 of treatment. Whole-genome sequence analysis for drug resistance was conducted at the South Africa National Institute for Communicable Diseases (Johannesburg, South Africa), and MIC testing with broth microdilution was conducted at the Institute of Tropical Medicine (Antwerp, Belgium).

Main Article

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Page updated: December 10, 2025
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