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Volume 31, Number 12—December 2025
Synopsis
Retrospective Multicenter Study of Human Granulocytic Anaplasmosis, France, 2012–2024
Victor Gerber
, Thomas Lemmet, Thomas Bonijoly, Baptiste Hoellinger, Anne Pachart, Amandine Woerly, Dominique De Briel, Emilie Talagrand-Reboul, Martin Martinot, Pierre Boyer, and Yves Hansmann
, Thomas Lemmet, Thomas Bonijoly, Baptiste Hoellinger, Anne Pachart, Amandine Woerly, Dominique De Briel, Emilie Talagrand-Reboul, Martin Martinot, Pierre Boyer, and Yves Hansmann
Table 2
Clinical and epidemiologic characteristics of 39 cases in a retrospective multicenter study of human granulocytic anaplasmosis, France, 2012–2024*
| Patient characteristics | Value |
|---|---|
| Tick bite <30 d | 24 (61.5) |
| Median time between tick bite and symptom onset, d (range) |
7 (1–28) |
| Travel history <30 d | |
| Outside France | 1 (2.6)† |
| In France, outside the study region |
3 (7.7) |
| Signs and symptoms | |
| Fever | 38 (97.4) |
| Fatigue | 24 (61.5) |
| Headache | 24 (61.5) |
| Chills | 15 (38.5) |
| Nausea | 12 (30.8) |
| Vomiting | 11 (28.2) |
| Abdominal pain | 10 (25.6) |
| Myalgia | 9 (23.1) |
| Anorexia | 8 (20.5) |
| Cough | 8 (20.5) |
| Other neurologic signs‡ | 5 (12.8) |
| Diarrhea | 5 (12.8) |
| Hepatomegaly | 4 (10.3) |
| Arthralgia | 3 (7.7) |
| Confusion | 3 (7.7) |
| Constipation | 2 (5.1) |
| Splenomegaly | 2 (5.1) |
| Rash | 2 (5.1) |
| Pneumonia | 1 (2.6) |
| Gravity signs | 3 (7.7) |
| Hypotension | 2 (5.1) |
| Hypoxia |
1 (2.6) |
| No. patients with complications | 13 (33.3) |
| Cardiac complications§ | 1 (2.6) |
| Pneumonitis | 3 (7.7) |
| Acute kidney injury | 7 (17.9) |
| Rhabdomyolysis | 5 (12.8) |
| Confirmed secondary hemophagocytic lymphohistiocytosis on myelogram | 1 (2.6) |
| Bleeding | 1 (2.6) |
*Values are no. (%) except as indicated. ARDS, acute respiratory distress syndrome. †Travel to Pennsylvania, USA. ‡Signs included dizziness, faintness, neuritis, or diadochokinesia. §Complications included cardiac arrhythmia and heart failure.
Page created: December 04, 2025
Page updated: December 15, 2025
Page reviewed: December 15, 2025
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