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Volume 31, Supplement—October 2025
SUPPLEMENT ISSUE
Supplement
Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017–2021
Courtney C. Nawrocki, Mark J. Delorey, Austin R. Earley, Sarah A. Hook, Kiersten J. Kugeler, Grace E. Marx, Paul S. Mead, and Alison F. Hinckley
Table 3
Average percentage difference in relative frequency of nonspecific symptoms between Lyme disease case-patients and control-patients over the postdiagnosis year in study of nonspecific symptoms attributable to Lyme disease in high-incidence areas, United States, 2017–2021
| Symptom | 2 mo postdiagnosis | 6 mo postdiagnosis | 12 mo postdiagnosis | % Difference (95% CI) between 2 and 12 mo | % Difference (95% CI) between 6 and 12 mo |
|---|---|---|---|---|---|
| Any symptom | 2.5 | 0.5 | 1.0 | 1.6 (1.0–2.2) | −0.5 (−1.0 to 0.06) |
| Pain | 1.2 | 0.0 | 0.4 | 0.8 (0.3–1.3) | −0.4 (−1.0 to −0.1) |
| Fatigue | 2.3 | 0.8 | 0.9 | 1.4 (1.1–1.7) | −0.1 (−0.4 to 0.2) |
| Cognitive difficulties | 0.3 | 0.0 | 0.1 | 0.2 (0.0–0.3) | −0.06 (−0.2 to 0.1) |
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