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Volume 31, Supplement—December 2025

SUPPLEMENT ISSUE
Supplement

Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017–2021

Courtney C. Nawrocki, Mark J. Delorey, Austin R. Earley, Sarah A. Hook, Kiersten J. Kugeler, Grace E. Marx, Paul S. Mead, and Alison F. HinckleyComments to Author 
Author affiliation: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (C.C. Nawrocki, M.J. Delorey, A.R. Earley, S.A. Hook, K.J. Kugeler, G.E. Marx, P.S. Mead, A.F. Hinckley); Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (A.R. Earley)

Main Article

Table 3

Average percentage difference in relative frequency of nonspecific symptoms between Lyme disease case-patients and control-patients over the postdiagnosis year in study of nonspecific symptoms attributable to Lyme disease in high-incidence areas, United States, 2017–2021

Symptom 2 mo postdiagnosis 6 mo postdiagnosis 12 mo postdiagnosis % Difference (95% CI) between 2 and 12 mo % Difference (95% CI) between 6 and 12 mo
Any symptom 2.5 0.5 1.0 1.6 (1.0–2.2) −0.5 (−1.0 to 0.06)
Pain 1.2 0.0 0.4 0.8 (0.3–1.3) −0.4 (−1.0 to −0.1)
Fatigue 2.3 0.8 0.9 1.4 (1.1–1.7) −0.1 (−0.4 to 0.2)
Cognitive difficulties 0.3 0.0 0.1 0.2 (0.0–0.3) −0.06 (−0.2 to 0.1)

Main Article

Page created: August 27, 2025
Page updated: January 22, 2026
Page reviewed: January 22, 2026
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