Volume 31, Supplement—December 2025
SUPPLEMENT ISSUE
Supplement
Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017–2021
Courtney C. Nawrocki, Mark J. Delorey, Austin R. Earley, Sarah A. Hook, Kiersten J. Kugeler, Grace E. Marx, Paul S. Mead, and Alison F. Hinckley
Table 1
Distribution of characteristics of among Lyme disease case-patients and matched control-patients in in study of nonspecific symptoms attributable to Lyme disease in high-incidence areas, United States, 2017–2021*
| Characteristic | No. (%) |
|
|---|---|---|
| Case-patients, n = 24,503† | Control-patients, n = 122,095 | |
| Year | ||
| 2017 | 6,550 (22.7) | 32,632 (22.7) |
| 2018 | 5,257 (23.2) | 26,140 (23.1) |
| 2019 | 5,303 (22.5) | 26,472 (22.5) |
| 2020 | 3,668 (17.5) | 18,267 (17.5) |
| 2021 |
3,725 (14.2) |
18,584 (14.2) |
| Age group, y | ||
| 0–17 | 6,101 (23.7) | 30,681 (23.8) |
| 18–34 | 3,587 (22.5) | 18,170 (22.8) |
| 35–44 | 3,398 (15.0) | 17,075 (15.1) |
| 45–54 | 5,582 (18.9) | 27,671 (18.8) |
| 55–64 |
5,835 (19.9) |
28,498 (19.5) |
| Sex | ||
| F | 11,088 (44.5) | 55,316 (44.6) |
| M |
13,415 (55.5) |
66,779 (55.4) |
| Season of onset | ||
| Winter, Dec–Feb | 1,670 (6.9) | 8,311 (6.9) |
| Spring, Mar–May | 4,316 (17.4) | 21,498 (17.4) |
| Summer, Jun–Aug | 13,704 (56.1) | 68,307 (56.1) |
| Fall, Sep–Nov |
4,813 (19.6) |
23,979 (19.6) |
| Diagnosis encounter type | ||
| Outpatient | 24,241 (98.9) | 120,978 (99.1) |
| Inpatient | 262 (1.1) | 1,117 (0.9) |
*Case-patients and control-patients were matched on age group, sex, Lyme disease diagnosis or healthcare visit date, and inpatient vs. outpatient status. †Unweighted frequencies reflect distributions of variables in the sample; weighted percents reflect distributions of variables in MarketScan database.
Page created: August 27, 2025
Page updated: January 22, 2026
Page reviewed: January 22, 2026
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