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Volume 31, Supplement—December 2025

SUPPLEMENT ISSUE
Supplement

Thrombotic Events and Stroke in the Year After COVID-19 or Other Acute Respiratory Infection

Caroline Q. PrattComments to Author , Alexandra F. Dalton, Emily H. Koumans, Abraham Agedew, Fatima Coronado, Elizabeth A. Lundeen, Rebecca C. Woodruff, Jason P. Block, Mark Weiner, Lindsay Cowell, Jonathan D. Arnold, Sharon Saydah, and PCORnet Network Partners1
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.Q. Pratt, A.F. Dalton, E.H. Koumans, A. Agedew, F. Coronado, E.A. Lundeen, R.C. Woodruff, S. Saydah); Harvard Pilgrim Health Care Institute & Harvard Medical School, Boston, Massachusetts, USA (J.P. Block); Weill Cornell Medicine, New York, New York, USA (M. Weiner); The University of Texas Southwestern Medical Center, Dallas, Texas, USA (L. Cowell); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA (J.D. Arnold)

Main Article

Table

Unadjusted incidence ratios of stroke and thrombotic events for patients with COVID-19 compared with ARI by hospitalization status and days from acute illness*

All events Unadjusted ratio of COVID-19 to ARI (95% CI)
All patients Hospitalized Nonhospitalized
All events 31–90 d and no record in 18 mo prior 1.52 (1.48–1.56) 1.11 (1.04–1.18) 1.62 (1.58–1.67)
Ischemic stroke 1.55 (1.49–1.61) 1.13 (1.02–1.25) 1.65 (1.58–1.73)
Deep vein thrombosis 1.51 (1.44–1.57) 1.12 (1.01–1.23) 1.62 (1.53–1.7)
Hemorrhagic stroke 1.47 (1.36–1.58) 0.99 (0.81–1.16) 1.71 (1.57–1.85)
Transient ischemic attack 1.56 (1.47–1.65) 1.2 (0.99–1.41) 1.6 (1.51–1.7)
Cerebral venous sinus thrombosis
 1.09 (0.72–1.45)
 0.92 (0.31–1.53)
 1.09 (0.63–1.54)
All events 91–180 d and no record in 18 mo prior 1.55 (1.52–1.59) 1.11 (1.04–1.18) 1.64 (1.61–1.68)
Ischemic stroke 1.63 (1.58–1.68) 1.26 (1.16–1.37) 1.68 (1.62–1.74)
Deep vein thrombosis 1.5 (1.44–1.56) 1.08 (0.97–1.19) 1.6 (1.53–1.66)
Hemorrhagic stroke 1.43 (1.34–1.53) 0.91 (0.73–1.09) 1.62 (1.51–1.73)
Transient ischemic attack 1.56 (1.49–1.64) 1.15 (0.94–1.35) 1.61 (1.53–1.69)
Cerebral venous sinus thrombosis
 1.35 (1.03–1.66)
 0.87 (0.24–1.49)
 1.49 (1.12–1.85)
All events 181–365 d and no record in 18 mo prior 1.64 (1.62–1.66) 1.12 (1.07–1.18) 1.73 (1.71–1.76)
Ischemic stroke 1.68 (1.64–1.72) 1.16 (1.07–1.25) 1.77 (1.73–1.82)
Deep vein thrombosis 1.62 (1.57–1.66) 1.08 (0.98–1.19) 1.73 (1.68–1.78)
Hemorrhagic stroke 1.58 (1.51–1.65) 0.92 (0.77–1.08) 1.79 (1.7–1.87)
Transient ischemic attack 1.69 (1.63–1.74) 1.34 (1.18–1.49) 1.72 (1.66–1.77)
Cerebral venous sinus thrombosis
 1.38 (1.16–1.6)
 1.13 (0.6–1.66)
 1.4 (1.15–1.65)
All events 31–365 d and no record in 18 mo prior 1.63 (1.61–1.65) 1.14 (1.1–1.18) 1.73 (1.71–1.76)
Ischemic stroke 1.67 (1.64–1.7) 1.2 (1.14–1.27) 1.76 (1.73–1.8)
Deep vein thrombosis 1.59 (1.55–1.62) 1.11 (1.04–1.18) 1.7 (1.66–1.74)
Hemorrhagic stroke 1.56 (1.51–1.62) 0.98 (0.87–1.09) 1.77 (1.7–1.84)
Transient ischemic attack 1.42 (1.37–1.46) 1.27 (1.16–1.39) 1.42 (1.37–1.46)
Cerebral venous sinus thrombosis 1.36 (1.18–1.55) 0.95 (0.53–1.37) 1.44 (1.23–1.65)

*Bold indicates statistically significant ratios. ARI, acute respiratory illness

Main Article

1Members of the PCORnet Network Partners group are listed at the end of this article.

Page created: December 15, 2025
Page updated: January 22, 2026
Page reviewed: January 22, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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