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Volume 31, Number 3—March 2025
Dispatch
Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy
Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, and Seppo Meri
Table 1
Blood culture results and body temperature of case patient from study of meningococcal sepsis in patient with paroxysmal nocturnal hemoglobinuria during pegcetacoplan therapy*
| Parameter | Reference range | Day −29 | Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
|---|---|---|---|---|---|---|---|---|
| Hemoglobin, g/L | 117–155 | 94 | 86 | 73† | 72† | 80 | 76† | 99 |
| Total leukocytes, × 109 cells/L | 3.4–8.2 | 1.8 | 2.5 | 1.8 | 3.1 | 2.3 | 2.2 | 3.4 |
| Neutrophils, × 109 cells/L | 1.5–6.7 | 0.60 | 1.90 | 1.46 | 2.02 | 1.33 | 0.89 | 1.81 |
| CRP, g/L | <4 | <4 | 21 | 67 | 202 | 102 | 54 | 32 |
| LDH, U/L | 115–235 | 362 | 398 | 463 | 726 | 619 | 493 | 452 |
| Fever, °C | 36–37 | NA | 39.5 | 40.1 | <38 | <37.5 | NA | NA |
*Day 0 indicates day patient sought hospital care. CRP, C-reactive protein; LDH, lactate dehydrogenase; NA, not available. †Packed red blood cell transfusions.
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