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Volume 31, Number 3—March 2025
Dispatch

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006–2022

Roxana Paul1, Federico Lorenzo1, Beatriz López, María Gabriela Alegre, David Couvin, Nalin Rastogi, Laura Pérez-Lago, Darío García de Viedma, Ana Gamberale, Norma González, Domingo Palmero, Silvia Altabe, Norberto Simboli, and Noemí Kaoru YokoboriComments to Author 
Author affiliation: Instituto Nacional de Enfermedades Infecciosas, ANLIS “Dr. C. G. Malbrán,” Buenos Aires, Argentina (R. Paul, F. Lorenzo, B. López, N. Simboli, N.K. Yokobori); Programa de Control de Tuberculosis, Chaco, Argentina (M.G. Alegre, S. Altabe); Université des Antilles, Guadeloupe, France (D. Couvin); Institut Pasteur de Guadeloupe, Abymes, Guadeloupe (D. Couvin, N. Rastogi); Hospital General Universitario Gregorio Marañón, Madrid, Spain (L. Pérez-Lago, D. García de Viedma); Instituto de Investigaciòn Sanitaria Gregorio Marañón, Madrid (L. Pérez-Lago, D. García de Viedma); Instituto de Salud Carlos III, Madrid (D. García de Viedma); CIBER Enfermedades Respiratorias, Madrid (D. García de Viedma); Hospital Muñiz, Buenos Aires (A. Gamberale, D. Palmero); Instituto Vaccarezza, Buenos Aires (A. Gamberale, D. Palmero); Hospital General de Niños “Pedro de Elizalde,” Buenos Aires (N. González); National Scientific and Technical Research Council, Buenos Aires (N.K. Yokobori)

Main Article

Figure 1

Maximum-likelihood phylogenetic tree of the 24 isolates from the MDR Mycobacterium tuberculosis outbreak strain Ch, Chaco, Argentina, 2006–2022, analyzed by whole-genome sequencing. Each patient is represented by a colored dot. Labels indicate the patient and isolate identification numbers. Blocks indicate the resistance-conferring mutations detected in each isolate, as indicated below the tree. Scale bar indicates number of substitutions per variable site. MDR, multidrug-resistant.

Figure 1. Maximum-likelihood phylogenetic tree of the 24 isolates from the MDR Mycobacterium tuberculosis outbreak strain Ch, Chaco, Argentina, 2006–2022, analyzed by whole-genome sequencing. Each patient is represented by a colored dot. Labels indicate the patient and isolate identification numbers. Blocks indicate the resistance-conferring mutations detected in each isolate, as indicated below the tree. Scale bar indicates number of substitutions per variable site. MDR, multidrug-resistant.

Main Article

1These first authors contributed equally to this article.

Page created: February 04, 2025
Page updated: March 05, 2025
Page reviewed: March 05, 2025
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