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Volume 31, Number 3—March 2025
CME ACTIVITY - Research

Efficacy and Safety of 4-Month Rifapentine-Based Tuberculosis Treatments in Persons with Diabetes

Ekaterina V. KurbatovaComments to Author , William C. Whitworth, Lakshmi Praveena Peddareddy, Patrick P.J. Phillips, Nigel A. Scott, Kia E. Bryant, Rodney Dawson, Sandra Wagner Cardoso, Wadzanai Samaneka, Melissa Engle, Ziyaad Waja, Erin Sizemore, Wendy Carr, Kelly E. Dooley, Radojka Savic, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, Payam Nahid, Nhung V. Nguyen, and AIDS Clinical Trials Group A5349,1 and Tuberculosis Trials Consortium Study 312
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.V. Kurbatova, W.C. Whitworth, L.P. Peddareddy, N.A. Scott, K.E. Bryant, E. Sizemore, W. Carr); University of California– San Francisco Center for Tuberculosis, San Francisco, California, USA (P.P.J. Phillips, R. Savic, P. Nahid); University of Cape Town Lung Institute, Cape Town, South Africa (R. Dawson); Fundação Oswaldo Cruz Insituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil (S. Wagner Cardoso); Milton Park Clinical Research Site, Harare, Zimbabwe (W. Samaneka); Audie L. Murphy Veterans Administration Medical Center, San Antonio, Texas, USA (M. Engle); Wits Health Consortium Perinatal HIV Research Unit, Johannesburg, South Africa (Z. Waja); Vanderbilt University Medical Center, Nashville, Tennessee, USA (K.E. Dooley); University of Nebraska Medical Center, Omaha, Nebraska, USA (S. Swindells); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (R.E. Chaisson); Medical University of South Carolina, Charleston, South Carolina, USA (S.E. Dorman); Vietnam National Tuberculosis Program/University of California–San Francisco Research Collaboration Unit, Hanoi, Vietnam (N.V. Nguyen)

Main Article

Table 1

Diabetes status of 181 participants at enrollment, by tuberculosis drug regimen, in a study assessing efficacy and safety of 4-month rifapentine-based tuberculosis treatments in persons with diabetes at sites in 12 countries,* January 2016–October 2018

Criterion† No. patients (%)
Control, n = 59 Rifapentine/moxifloxacin, n = 66 Rifapentine, n = 56 Total, N = 181
Hemoglobin A1c >6.5% 49 (83.1) 43 (65.2) 43 (76.8) 135 (74.6)
Prior reported diagnosis of diabetes 31 (52.5) 36 (54.5) 16 (28.6) 83 (45.9)
Receiving antidiabetic drugs‡ 22 (37.3) 29 (43.9) 11 (19.6) 62 (34.3)
Fasting blood glucose >126 mg/dL 14 (23.7) 18 (27.3) 13 (23.2) 45 (24.9)
Nonfasting blood glucose >200 mg/dL 5 (8.5) 13 (19.7) 4 (7.1) 22 (12.2)

*Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, United States, Vietnam, and Zimbabwe. †Diabetes criteria were assessed at enrollment (baseline). Randomized trial participants meeting >1 of these criteria at enrollment were included in these analyses. ‡World Health Organization Drug Dictionary’s standardized drug groupings were used to identify class 2 category drugs used in diabetes (18).

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1Members of group listed at the end of this article.

2Members of group listed at the end of this article.

Page created: January 15, 2025
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