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Volume 31, Number 3—March 2025
Dispatch

Donor-Derived Ehrlichiosis Caused by Ehrlichia chaffeensis from Living Donor Kidney Transplant

Michael J. Scolarici1Comments to Author , Daniel Kuehler1, Rebecca Osborn, Annie Doyle, Elizabeth K. Schiffman, Alex Garvin, Julian A. Villalba, Carmen J. Ramos, Christopher D. Paddock, Pallavi D. Annambhotla, Marissa Taylor, Johanna S. Salzer, Christopher Saddler, Carrie Thiessen, Raja Kandaswamy2, and Jon Odorico2
Author affiliation: University of Wisconsin–Madison School of Medicine and Public Health, Madison, Wisconsin, USA (M.J. Scolarici, C. Saddler, C. Thiessen, J. Odorico); University of Minnesota, Minneapolis, Minnesota, USA (D. Kuehler, A. Doyle, R. Kandaswamy); Wisconsin Department of Health Services, Madison (R. Osborn); Minnesota Department of Health, St. Paul, Minnesota, USA (E.K. Schiffman, A. Garvin); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.A. Villalba, C.J. Ramos, C.D. Paddock, P.D. Annambhotla, M. Taylor, J.S. Salzer)

Main Article

Table

Summary of Ehrlichia testing of living donor and recipient from donor-derived ehrlichiosis caused by Ehrlichia chaffeensis from living donor kidney transplant*

Days from kidney donation Specimen IgG IFA titer† Real-time PCR‡ 16S rRNA gene PCR§ Immunohistochemical assay¶
Donor
−10 Serum 1:128 Negative ND ND
0 Serum 1:128 Negative ND ND
20 Serum 1:256 ND ND ND
119
 Serum
 1:512
 ND
 ND
 ND
Recipient
−15 Serum ND Negative ND ND
0 Serum ND Negative ND ND
11 Perinephric fluid ND ND E. chaffeensis detected ND
14 Blood ND Positive ND ND
16 Renal tissue biopsy ND ND ND Ehrlichia spp. antigens detected

*IFA, indirect fluorescent antibody; ND, not done. †Testing performed at the Centers for Disease Control and Prevention. ‡Testing performed at the Centers for Disease Control and Prevention and Mayo Clinic Laboratories. Negative results defined as no bacterial DNA detected by real-time PCR. §Testing performed at University of Wisconsin Hospital Laboratory. ¶Testing performed at the Centers for Disease Control and Prevention.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: February 04, 2025
Page updated: February 24, 2025
Page reviewed: February 24, 2025
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