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Volume 31, Number 5—May 2025
Research

Postexposure Antimicrobial Drug Therapy in Goats Infected with Burkholderia pseudomallei

Richard A. BowenComments to Author , Airn E. Hartwig, Angela M. Bosco-Lauth, Josilene N. Seixas, Jana M. Ritter, Pamela S. Fair, Mindy G. Elrod, Zachary P. Weiner, Robyn A. Stoddard, Antonio R. Vieira, Rachel M. Maison, Elizabeth Lawrence, Hannah Sueper, Mckinzee Barker, and William A. Bower
Author affiliation: Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado, USA (R.A. Bowen, A.E. Hartwig, A.M. Bosco-Lauth, R.M. Maison, E. Lawrence, H. Sueper, M. Barker); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.N. Seixas, J.M. Ritter, P.S. Fair, M.G. Elrod, Z.P. Weiner, R.A. Stoddard, A.R. Vieira, W.A. Bower)

Main Article

Figure 1

Pharmacokinetic analysis of antibiotics used to study postexposure antimicrobial drug therapy in goats infected with Burkholderia pseudomallei. Two female goats received a mixture of 1 capsule containing sulfamethoxazole (800 mg) and trimethoprim (160 mg) plus 1 capsule containing amoxicillin (500 mg) and clavulanate (125 mg) in a total of 25 mL of water. We repeated the treatment 12 hours later and collected blood samples at 1, 2, 4, 9, 24, 36, and 48 hours after the initial treatment. Concentrations of amoxicillin (A), sulfamethoxazole (B), and trimethoprim (B) over the 48-hour period showed acceptable blood levels of the rugs after oral administration.

Figure 1. Pharmacokinetic analysis of antibiotics used to study postexposure antimicrobial drug therapy in goats infected with Burkholderia pseudomallei. Two female goats received a mixture of 1 capsule containing sulfamethoxazole (800 mg) and trimethoprim (160 mg) plus 1 capsule containing amoxicillin (500 mg) and clavulanate (125 mg) in a total of 25 mL of water. We repeated the treatment 12 hours later and collected blood samples at 1, 2, 4, 9, 24, 36, and 48 hours after the initial treatment. Concentrations of amoxicillin (A), sulfamethoxazole (B), and trimethoprim (B) over the 48-hour period showed acceptable blood levels of the rugs after oral administration.

Main Article

Page created: March 13, 2025
Page updated: April 22, 2025
Page reviewed: April 22, 2025
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