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Volume 31, Number 5—May 2025
Research

Postexposure Antimicrobial Drug Therapy in Goats Infected with Burkholderia pseudomallei

Richard A. BowenComments to Author , Airn E. Hartwig, Angela M. Bosco-Lauth, Josilene N. Seixas, Jana M. Ritter, Pamela S. Fair, Mindy G. Elrod, Zachary P. Weiner, Robyn A. Stoddard, Antonio R. Vieira, Rachel M. Maison, Elizabeth Lawrence, Hannah Sueper, Mckinzee Barker, and William A. Bower
Author affiliation: Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado, USA (R.A. Bowen, A.E. Hartwig, A.M. Bosco-Lauth, R.M. Maison, E. Lawrence, H. Sueper, M. Barker); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.N. Seixas, J.M. Ritter, P.S. Fair, M.G. Elrod, Z.P. Weiner, R.A. Stoddard, A.R. Vieira, W.A. Bower)

Main Article

Table 2

Comparison of bacterial culture and abscesses observed at necropsy or by histologic evaluation of major organs by treatment group in evaluation of postexposure antimicrobial drug therapy in goats infected with Burkholderia pseudomallei*

Observation Treatment
None Amoxicillin/clavulanate Sulfamethoxazole/trimethoprim Sulfamethoxazole/trimethoprim + amoxicillin/clavulanate
No. goats with >1 positive B. pseudomallei tissue culture
6 of 8
 8 of 8
 4 of 8
 0 of 8
Organs with macroscopic abscesses
Spleen 8 of 8 8 of 8 5 of 8 0 of 8
Lungs 4 of 16 10 of 16 3 of 15 0 of 16
Liver 0 of 8 3 of 8 0 of 8 0 of 8
Kidney
 0 of 8
 3 of 8
 0 of 8
 0 of 8
Organs with microscopic abscesses
Spleen 6 of 8 8 of 8 5 of 8 0 of 8
Lungs 3 of 16 11 of 16 0 of 15 0 of 16
Liver 1 of 8 3 of 8 0 of 8 0 of 8
Lymph nodes 5 of 8 8 of 8 2 of 8 0 of 8
Kidney 0 of 8 0 of 7 0 of 8 0 of 8

*Statistical analyses of differences between treatment groups are available (Appendix Table 2)

Main Article

Page created: March 13, 2025
Page updated: April 22, 2025
Page reviewed: April 22, 2025
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