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Volume 31, Number 5—May 2025
Research

Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms

Nissrine Abou-Chakra, Karen Marie Thyssen Astvad, Jan Martinussen, Amalie Sofie Eilsø Munksgaard, and Maiken Cavling ArendrupComments to Author 
Author affiliation: Author affiliations: Statens Serum Institut, Copenhagen, Denmark (N. Abou-Chakra, K.M.T. Astvad, A.S.E. Munksgaard, M.C. Arendrup); Technical University of Denmark, Kgs Lyngby, Denmark (J. Martinussen); University of Copenhagen, Copenhagen (A.S.E. Munksgaard, M.C. Arendrup); Rigshospitalet, Copenhagen (M.C. Arendrup)

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Figure 2

FCY2 sequence encoding the purine-cytosine permease derived from contig 14 of the Candida tropicalis strain ATCC 750 genome assembly, published on the ATCC Genome Portal in 2020. The coding sequence spans positions 2152980–2154500. The ORF is depicted at the top left of the figure; long red arrow illustrates the FCY2 forward primer designed by Desnos-Ollivier et al. (12), and the blue arrow indicating the ORF they used. The green arrow represents the tryptophan codon TGG, which is converted to stop codon TGA in the MYA 3404 genome assembly. CDS, coding sequence; ORF, open reading frame.

Figure 2. FCY2 sequence encoding the purine-cytosine permease derived from contig 14 of the Candida tropicalis strain ATCC 750 genome assembly, published on the ATCC Genome Portal in 2020. The coding sequence spans positions 2152980–2154500. The ORF is depicted at the top left of the figure; long red arrow illustrates the FCY2 forward primer designed by Desnos-Ollivier et al. (12), and the blue arrow indicating the ORF they used. The green arrow represents the tryptophan codon TGG, which is converted to stop codon TGA in the MYA 3404 genome assembly. CDS, coding sequence; ORF, open reading frame.

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