Volume 31, Number 5—May 2025
Research
Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms
Nissrine Abou-Chakra, Karen Marie Thyssen Astvad, Jan Martinussen, Amalie Sofie Eilsø Munksgaard, and Maiken Cavling Arendrup
Table 2
5-fluorocytosine susceptibility of Candida spp. in study of clonal expansion of 5-fluorocytosine–resistant Candida tropicalis, Denmark*
| Year sampled | MIC, mg/L |
Total | Wild-type UL, mg/L | Non–wild-type rate, % | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <0.016 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
| C. tropicalis | |||||||||||||||
| 1998–2004 | 0 | 1 | 2 | 17 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 25 | 0.5 | 4.0 |
| 2011–12 | 0 | 0 | 12 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 23 | 0.5 | 17.4 |
| 2022 |
1 |
1 |
9 |
18 |
2 |
1 |
0 |
0 |
0 |
0 |
3 |
29 |
64 |
0.5 |
50.0 |
| C. albicans | |||||||||||||||
| 2022 |
0 |
2 |
8 |
144 |
154 |
28 |
14 |
2 |
0 |
0 |
0 |
1 |
353 |
1 |
0.8 |
| C. glabrata | |||||||||||||||
| 2022 | 1 | 8 | 86 | 122 | 5 | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 227 | 0.25 | 2.2 |
*The reference strain, Candida tropicalis ATCC 750, had a MIC of 0.06 mg/L. Bold text indicates non–wild-type isolates. UL, upper limit.
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Page updated: April 25, 2025
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