Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 31, Number 5—May 2025
Research
Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms
Nissrine Abou-Chakra, Karen Marie Thyssen Astvad, Jan Martinussen, Amalie Sofie Eilsø Munksgaard, and Maiken Cavling Arendrup
Table 2
5-fluorocytosine susceptibility of Candida spp. in study of clonal expansion of 5-fluorocytosine–resistant Candida tropicalis, Denmark*
| Year sampled | MIC, mg/L |
Total | Wild-type UL, mg/L | Non–wild-type rate, % | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <0.016 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
| C. tropicalis | |||||||||||||||
| 1998–2004 | 0 | 1 | 2 | 17 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 25 | 0.5 | 4.0 |
| 2011–12 | 0 | 0 | 12 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 23 | 0.5 | 17.4 |
| 2022 |
1 |
1 |
9 |
18 |
2 |
1 |
0 |
0 |
0 |
0 |
3 |
29 |
64 |
0.5 |
50.0 |
| C. albicans | |||||||||||||||
| 2022 |
0 |
2 |
8 |
144 |
154 |
28 |
14 |
2 |
0 |
0 |
0 |
1 |
353 |
1 |
0.8 |
| C. glabrata | |||||||||||||||
| 2022 | 1 | 8 | 86 | 122 | 5 | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 227 | 0.25 | 2.2 |
*The reference strain, Candida tropicalis ATCC 750, had a MIC of 0.06 mg/L. Bold text indicates non–wild-type isolates. UL, upper limit.
Page created: April 14, 2025
Page updated: April 22, 2025
Page reviewed: April 22, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.