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Volume 31, Number 5—May 2025
Dispatch

High Prevalence of Influenza D Virus Infection in Swine, Northern Ireland

Paula Lagan and Ken LemonComments to Author 
Author affiliation: Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast, Northern Ireland

Main Article

Figure 2

Amino acid substitutions in swine-origin influenza D virus HEF protein relative to bovine-origin influenza D virus, Northern Ireland. Changes relative to the bovine-origin sequence are displayed. Amino acid numbering is according to Song et al. (6). Substitutions occurring at the receptor-binding site and esterase are highlighted with red text on a blue background. Sequence conservation at each position is indicated by logo generated at WebLogo (https://weblogo.berkeley.edu/logo.cgi) (bottom) on the basis of alignment of 169 influenza D virus sequences. HEF, hemagglutinin-esterase fusion; NI, Northern Ireland.

Figure 2. Amino acid substitutions in swine-origin influenza D virus HEF protein relative to bovine-origin influenza D virus, Northern Ireland. Changes relative to the bovine-origin sequence are displayed. Amino acid numbering is according to Song et al. (6). Substitutions occurring at the receptor-binding site and esterase are highlighted with red text on a blue background. Sequence conservation at each position is indicated by logo generated at WebLogo (https://weblogo.berkeley.edu/logo.cgi) (bottom) on the basis of alignment of 169 influenza D virus sequences. HEF, hemagglutinin-esterase fusion; NI, Northern Ireland.

Main Article

References
  1. Kwasnik  M, Rola  J, Rozek  W. Influenza D in domestic and wild animals. Viruses. 2023;15:2433. DOIPubMedGoogle Scholar
  2. Gaudino  M, Chiapponi  C, Moreno  A, Zohari  S, O’Donovan  T, Quinless  E, et al. Evolutionary and temporal dynamics of emerging influenza D virus in Europe (2009-22). Virus Evol. 2022;8:veac081. DOIPubMedGoogle Scholar
  3. Dane  H, Duffy  C, Guelbenzu  M, Hause  B, Fee  S, Forster  F, et al. Detection of influenza D virus in bovine respiratory disease samples, UK. Transbound Emerg Dis. 2019;66:2184–7. DOIPubMedGoogle Scholar
  4. Hause  BM, Ducatez  M, Collin  EA, Ran  Z, Liu  R, Sheng  Z, et al. Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog. 2013;9:e1003176. DOIPubMedGoogle Scholar
  5. Lagan  P, Hamil  M, Cull  S, Hanrahan  A, Wregor  RM, Lemon  K. Swine influenza A virus infection dynamics and evolution in intensive pig production systems. Virus Evol. 2024;10:veae017. DOIPubMedGoogle Scholar
  6. Song  H, Qi  J, Khedri  Z, Diaz  S, Yu  H, Chen  X, et al. An open receptor-binding cavity of hemagglutinin-esterase-fusion glycoprotein from newly identified influenza D virus: basis for its broad cell tropism. PLoS Pathog. 2016;12:e1005411. DOIPubMedGoogle Scholar
  7. Gorin  S, Richard  G, Hervé  S, Eveno  E, Blanchard  Y, Jardin  A, et al. Characterization of influenza D virus reassortant strain in swine from mixed pig and beef farm, France. Emerg Infect Dis. 2024;30:1672–6. DOIPubMedGoogle Scholar
  8. Kaplan  BS, Falkenberg  S, Dassanayake  R, Neill  J, Velayudhan  B, Li  F, et al. Virus strain influenced the interspecies transmission of influenza D virus between calves and pigs. Transbound Emerg Dis. 2021;68:3396–404. DOIPubMedGoogle Scholar
  9. Gorin  S, Richard  G, Quéguiner  S, Chastagner  A, Barbier  N, Deblanc  C, et al. Pathogenesis, transmission, and within-host evolution of bovine-origin influenza D virus in pigs. Transbound Emerg Dis. 2024;2024:9009051. DOIGoogle Scholar

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Page created: March 11, 2025
Page updated: April 25, 2025
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