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Volume 31, Number 5—May 2025

Dispatch

High Prevalence of Influenza D Virus Infection in Swine, Northern Ireland

Paula Lagan and Ken LemonComments to Author 
Author affiliation: Veterinary Sciences Division, Agri-Food and Biosciences Institute, Belfast, Northern Ireland

Main Article

Figure 3

Locations of amino acid substitutions in swine-origin influenza D virus HEF protein structure, for high prevalence of influenza D virus infection in swine, Northern Ireland. A) Homology model of D/bovine/Northern_Ireland/24280/2017 hemagglutinin-esterase fusion protein generated with Swiss-Model (https://swissmodel.expasy.org) by using the structure of D/swine/Oklahoma/1334/2011 (https://doi.org/10.2210/pdb5e64/pdb) as a template. B) Close-up of receptor-binding site. C) Close-up of esterase. Homology model was annotated in ChimeraX version 1.8 (https://www.cgl.ucsf.edu/chimerax). Blue indicates receptor-binding site (F127, T171, A172, S173, W185, F229, Y231, T239, F240, V273, V275, F297) and esterase (S57, G85, N117, R326, D356, H359) residues. Pink indicates residues substituted in swine-origin isolates.

Figure 3. Locations of amino acid substitutions in swine-origin influenza D virus HEF protein structure, for high prevalence of influenza D virus infection in swine, Northern Ireland. A) Homology model of D/bovine/Northern_Ireland/24280/2017 hemagglutinin-esterase fusion protein generated with Swiss-Model (https://swissmodel.expasy.org) by using the structure of D/swine/Oklahoma/1334/2011 (https://doi.org/10.2210/pdb5e64/pdb) as a template. B) Close-up of receptor-binding site. C) Close-up of esterase. Homology model was annotated in ChimeraX version 1.8 (https://www.cgl.ucsf.edu/chimerax). Blue indicates receptor-binding site (F127, T171, A172, S173, W185, F229, Y231, T239, F240, V273, V275, F297) and esterase (S57, G85, N117, R326, D356, H359) residues. Pink indicates residues substituted in swine-origin isolates.

Main Article

Page created: March 11, 2025
Page updated: April 25, 2025
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