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Volume 31, Number 5—May 2025

Research

Detection of SARS-CoV-2 Reinfections Using Nucleocapsid Antibody Boosting

Eduard GrebeComments to Author , Daniel Chacreton, Mars Stone, Bryan R. Spencer, James Haynes, Akintunde Akinseye, Marion C. Lanteri, Valerie Green, Hasan Sulaeman, Roberta Bruhn, Vivian I. Avelino-Silva, Paul Contestable, Brad J. Biggerstaff, Melissa M. Coughlin, Brian Custer, Jefferson M. Jones, David Wright1, and Michael P. Busch1
Author affiliation: Vitalant Research Institute, San Francisco, California, USA (E. Grebe, M. Stone, H. Sulaeman, R. Bruhn, V.I. Avelino-Silva, B. Custer, M.P. Busch); Westat, Rockville, Maryland, USA (D. Chacreton, A. Akinseye, D. Wright); University of California San Francisco, San Francisco (M. Stone, R. Bruhn, B. Custer, M.P. Busch); American Red Cross, Dedham, Massachusetts, USA (B.R. Spencer); American Red Cross, Rockville (J.M. Haynes); Creative Testing Solutions, Tempe, Arizona, USA (M.C. Lanteri, V. Green); San Francisco State University, San Francisco (H. Sulaeman); QuidelOrtho, Rochester, New York, USA (P. Contestable); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (B.J. Biggerstaff); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.M. Coughlin, J.M. Jones)

Main Article

Figure 3

PPV and NPV in a study of detection of SARS-CoV-2 reinfections using nucleocapsid antibody boosting. A) Unweighted threshold ratio >1.43. B) Weighted threshold ratio >2.33. Predictive values were calculated as a function of percentage of a population of blood donors experiencing SARS-CoV-2 reinfection, at different rates of reinfection. Vertical red lines indicate the proportions reinfected that represent the optimal scenarios for the given threshold ratio, i.e., where PPV and NPV are simultaneously maximized. NPV, negative predictive value; PPV, positive predictive value.

Figure 3. PPV and NPV in a study of detection of SARS-CoV-2 reinfections using nucleocapsid antibody boosting. A) Unweighted threshold ratio >1.43. B) Weighted threshold ratio >2.33. Predictive values were calculated as a function of percentage of a population of blood donors experiencing SARS-CoV-2 reinfection, at different rates of reinfection. Vertical red lines indicate the proportions reinfected that represent the optimal scenarios for the given threshold ratio, i.e., where PPV and NPV are simultaneously maximized. NPV, negative predictive value; PPV, positive predictive value.

Main Article

1These senior authors contributed equally to this article.

Page created: March 25, 2025
Page updated: April 25, 2025
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