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Volume 31, Number 6—June 2025

Research

High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017

Tani Ly1, Marcus de Melo Teixeira1, Gaston I. Jofre1, Denis Blanchet, Sigrid MacDonald, Primavera Alvarado, Silvia Helena Marques da Silva, Victoria E. Sepúlveda, Qandeel Zeb, Stephen Vreden, Antoine Adenis, Francisco Yegres, Magalie Demar, Maria José Serna Buitrago, Bridget M. Barker, Mathieu Nacher, and Daniel R. MatuteComments to Author 
Author affiliation: Université de la Guyane, Cayenne, French Guiana (T. Ly); Universidade de Brasilia, Brasilia, Brazil (M. de Melo Teixeira); Northern Arizona University, Flagstaff, Arizona, USA (M. de Melo Teixeira, B.M. Barker); Virginia Commonwealth University, Richmond, Virginia, USA (G.I. Jofre); Centre Hospitalier de Cayenne, Cayenne (D. Blanchet, A. Adenis); University of Amsterdam, Amsterdam, Netherlands (S. MacDonald); Instituto de Biomedicina, Caracas, Venezuela (P. Alvarado); Evandro Chagas Institute, Ananindeua, Brazil (S.H. Marques da Silva); University of North Carolina, Chapel Hill, North Carolina, USA (V.E. Sepúlveda, Q. Zeb, F. Yegres, D.R. Matute); Foundation of Scientific Research Suriname, Paramaribo, Suriname (S. Vreden); Centre hospitalier Andree Rosemon, Cayenne (M. Demar); Instituto de Salud Carlos III, Madrid, Spain (M.J.S. Buitrago); Centre d'Investigation Clinique Antilles Guyane, Cayenne (M. Nacher).

Main Article

Table

The number of cases of histoplasmosis caused by each lineage of histoplasma, the number of patients who are HIV positive, the number of patients with the disseminated form of the disease, and the sex ratio of patients with histoplasma, the amazon basin, 2006–2017*

Lineage No. cases HIV positive Disseminated disease Sex
 χ2 power p value†
M F Ratio
mz5-like
 45
 40
 25
 30
 15
 2.00
 0.918
 χ2 = 1.931, d.f. = 1, p = 0.165
H. capsulatum subspecies
 15
 11
 8
 14
 1
 14.00
 0.491
 χ2 = 4.9658, d.f. = 1, p = 0.026
Amazon I
 8
 4
 3
 5
 3
 1.67
 0.293
 NA
Amazon II
 4
 4
 2
 2
 2
 2.00
 0.232
 NA
H. suramericanum
 15
 3
 2
 6
 2
 3.00
 0.293
 NA
Latin American group B 1 1 0 0 1 NA NA NA

*d.f., degrees of freedom; NA, not applicable. †By χ2 test.

Main Article

1These first authors contributed equally to this article.

Page created: May 01, 2025
Page updated: May 27, 2025
Page reviewed: May 27, 2025
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