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Volume 31, Number 6—June 2025

Research

High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017

Tani Ly1, Marcus de Melo Teixeira1, Gaston I. Jofre1, Denis Blanchet, Sigrid MacDonald, Primavera Alvarado, Silvia Helena Marques da Silva, Victoria E. Sepúlveda, Qandeel Zeb, Stephen Vreden, Antoine Adenis, Francisco Yegres, Magalie Demar, Maria José Serna Buitrago, Bridget M. Barker, Mathieu Nacher, and Daniel R. MatuteComments to Author 
Author affiliation: Université de la Guyane, Cayenne, French Guiana (T. Ly); Universidade de Brasilia, Brasilia, Brazil (M. de Melo Teixeira); Northern Arizona University, Flagstaff, Arizona, USA (M. de Melo Teixeira, B.M. Barker); Virginia Commonwealth University, Richmond, Virginia, USA (G.I. Jofre); Centre Hospitalier de Cayenne, Cayenne (D. Blanchet, A. Adenis); University of Amsterdam, Amsterdam, Netherlands (S. MacDonald); Instituto de Biomedicina, Caracas, Venezuela (P. Alvarado); Evandro Chagas Institute, Ananindeua, Brazil (S.H. Marques da Silva); University of North Carolina, Chapel Hill, North Carolina, USA (V.E. Sepúlveda, Q. Zeb, F. Yegres, D.R. Matute); Foundation of Scientific Research Suriname, Paramaribo, Suriname (S. Vreden); Centre hospitalier Andree Rosemon, Cayenne (M. Demar); Instituto de Salud Carlos III, Madrid, Spain (M.J.S. Buitrago); Centre d'Investigation Clinique Antilles Guyane, Cayenne (M. Nacher).

Main Article

Table

The number of cases of histoplasmosis caused by each lineage of histoplasma, the number of patients who are HIV positive, the number of patients with the disseminated form of the disease, and the sex ratio of patients with histoplasma, the amazon basin, 2006–2017*

Lineage No. cases HIV positive Disseminated Sex
 χ2 power p value†
Male Female Ratio
mz5-like 45 40 25 30 15 2.00 0.918 χ2 = 1.931, d.f. = 1, p = 0.165
H. capsulatum subspecies 15 11 8 14 1 14.00 0.491 χ2 = 4.9658, d.f. = 1, p = 0.026
Amazon-I 8 4 3 5 3 1.67 0.293 NA
Amazon-II 4 4 2 2 2 2.00 0.232 NA
H. suramericanum 15 3 2 6 2 3.00 0.293 NA
Latin American group B 1 1 0 0 1 NA NA NA

*d.f., degrees of freedom. †By χ2 test.

Main Article

1These first authors contributed equally to this article.

Page created: May 01, 2025
Page updated: May 20, 2025
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