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Volume 31, Number 6—June 2025

Dispatch

OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia

Nadia JaidaneComments to Author , Wejdene Mansour, Lamia Tilouche, Pierre Châtre, Pauline François, Agnese Lupo, Saoussen Oueslati, Aymeric Jacquemin, Ali Lazzem, Sonia Karaborni, Laetitia Du Fraysseix, Yomna Ben Lamine, Nidhal Mahdhi, Abdelhalim Trabelsi, Jean-Yves Madec, Marisa Haenni, and Thierry Naas
Author affiliation: Université de Sousse Faculté de Médecine, Sousse, Tunisia (N. Jaidane, W. Mansour); Sahloul Hospital, Sousse (L. Tilouche); Anses Laboratoire de Lyon, Lyon, France (P. Châtre, P. François, A. Lupo, L. Du Fraysseix, J.-Y. Madec, M. Haenni); Inserm U1184, Le Kremlin-Bicêtre, France (S. Oueslati, A. Jacquemin, T. Naas); Sahloul University Hospital, Sousse (A. Lazzem, S. Karaborni, Y. Ben Lamine, N. Mahdhi, A. Trabelsi); Université Paris-Saclay BU Kremlin-Bicêtre, Le Kremlin-Bicêtre, France (T. Naas)

Main Article

Figure 1

Comparative genomic analysis of OXA-204 carbapenemase-positive Pseudomonas guariconensis isolated from a child in Tunisia, 2023, using P. guariconensis GenBank accession no. GCF_040822035 as the reference genome. The concentric ring represents the BLAST (https://blast.ncbi.nlm.nih.gov) results of the P. guariconensis isolate from this study, 65411, with the reference genome. The color intensity of the outer ring indicates the level of sequence similarity, with darker shades representing higher sequence identity percentages. Gaps in the outer ring indicate very low identity or absence of the region. The magnified segment is the site of the IS26-mediated insertion of a 119-kbp plasmid fragment in the chromosome of P. guariconensis 65411. In the magnified portion, resistance genes and the associated mobile elements likely involved in their mobility are indicated in blue. Genes involved in resistance to β-lactams are indicated in orange (β-lactamases), to aminoglycosides in light green, to chloramphenicol in orange, and to sulfonamides in yellow. GC, guanine-cytosine. Figure created using BRIG software, https://sourceforge.net/projects/brig.

Figure 1. Comparative genomic analysis of OXA-204 carbapenemase-positive Pseudomonas guariconensis isolated from a child in Tunisia, 2023, using P. guariconensis GenBank accession no. GCF_040822035 as the reference genome. The concentric ring represents the BLAST (https://blast.ncbi.nlm.nih.gov) results of the P. guariconensis isolate from this study, 65411, with the reference genome. The color intensity of the outer ring indicates the level of sequence similarity, with darker shades representing higher sequence identity percentages. Gaps in the outer ring indicate very low identity or absence of the region. The magnified segment is the site of the IS26-mediated insertion of a 119-kbp plasmid fragment in the chromosome of P. guariconensis 65411. In the magnified portion, resistance genes and the associated mobile elements likely involved in their mobility are indicated in blue. Genes involved in resistance to β-lactams are indicated in orange (β-lactamases), to aminoglycosides in light green, to chloramphenicol in orange, and to sulfonamides in yellow. GC, guanine-cytosine. Figure created using BRIG software, https://sourceforge.net/projects/brig.

Main Article

*These senior authors contributed equally to this article.

Page created: April 25, 2025
Page updated: May 27, 2025
Page reviewed: May 27, 2025
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