Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Volume 31, Number 7—July 2025

Research

Emergence of Flucytosine-Resistant Candida tropicalis Clade, the Netherlands

Fatima Zohra Delma1, Bram Spruijtenburg1, Jacques F. Meis, Auke W. de Jong, James Groot, Johanna Rhodes, Willem J.G. Melchers, Paul E. Verweij, Theun de Groot, Eelco F.J. Meijer2, and Jochem B. Buil2Comments to Author 
Author affiliation: Radboud University Medical Center, Nijmegen, the Netherlands (F.Z. Delma, B. Spruijtenburg, J.F. Meis, J. Rhodes, W.J.G. Melchers, P.E. Verweij, T. de Groot, E.F.J. Meijer, J.B. Buil); Canisius-Wilhelmina Hospital (CWZ)/Dicoon, Nijmegen (B. Spruijtenburg, T. de Groot, E.F.J. Meijer); University of Cologne, Cologne, Germany (J.F. Meis); National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (A.W. de Jong, J. Groot, P.E. Verweij)

Main Article

Figure 4

Phylogenetic analysis of global collection of Candida tropicalis isolates and 16 isolates from the Netherlands in study of flucytosine-resistant clade. Tree was constructed to compare SNPs. MLST numbers at branch tips correspond to clades. Bold font indicates isolates were flucytosine non–wild-type; red font indicates isolates originating in the Netherlands. Zoomed-in part of tree indicates the five 5-FC non-WT isolates from the Netherlands most closely related to C. tropicalis MSLT 15. Scale bars indicate number of SNPs. MLST, multilocus sequence typing; SNP, single-nucleotide polymorphism.

Figure 4. Phylogenetic analysis of global collection of Candida tropicalis isolates and 16 isolates from the Netherlands in study of flucytosine-resistant clade. Tree was constructed to compare SNPs. MLST numbers at branch tips correspond to clades. Bold font indicates isolates were flucytosine non–wild-type; red font indicates isolates originating in the Netherlands. Zoomed-in part of tree indicates the five 5-FC non-WT isolates from the Netherlands most closely related to C. tropicalis MSLT 15. Scale bars indicate number of SNPs. MLST, multilocus sequence typing; SNP, single-nucleotide polymorphism.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: May 15, 2025
Page updated: June 25, 2025
Page reviewed: June 25, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external