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Volume 31, Number 7—July 2025

Research

Disseminated Histoplasmosis in Persons Living with HIV, France and Overseas Territories,1992–2021

Mathieu NacherComments to Author , Esaïe Marshall, Firouze Bani-Sadr, Sandrine Peugny, Blandine Denis, Elise Ouedraogo, Sebastien Gallien, Agnes Meybeck, Ugo Françoise, Antoine Adenis, Nicolas Vignier, Pierre Couppié, Pierre Sellier, and Sophie Grabar
Author affiliation: Centre Hospitalier Universitaire de Guyane, Cayenne, French Guiana (M. Nacher, A. Adenis, N. Vignier); Université de Guyane, Cayenne (M. Nacher, A. Adenis, P. Couppié); Santé des Populations en Amazonie, Cayenne (M. Nacher, A. Adenis, P. Couppié); Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris, France (E. Marshall, S. Grabar); Centre Hospitalier Universitaire de Reims, Reims, France (F. Bani-Sadr); Centre Hospitalier Universitaire de Guadeloupe, Les Abymes, Guadeloupe (S. Peugny); Hôpital Saint Louis, Paris, France (B. Denis); Centre Hospitalier Universitaire La Pitié Salpêtrière, Paris (E. Ouedraogo); Hôpital Henri-Mondor, Créteil, France (S. Gallien); Centre Hospitalier de Tourcoing, Tourcoing, France (A. Meybeck); Hôpital Saint Antoine, Paris, France (U. Françoise); Hôpital Avicenne, Bobigny, France (U. Françoise, N. Vignier); Université Paris Cité, Paris, France (N. Vignier); Université Sorbonne Paris Nord, Paris (N. Vignier); Centre Hospitalier Universitaire de Guyane, Cayenne, French Guiana (P. Couppié); Hôpital Lariboisière, Paris, France (P. Sellier); Hôpital St Antoine, Paris (S. Grabar)

Main Article

Table 1

Summary characteristics of first disseminated histoplasmosis cases among persons living with HIV from the French Hospital Database on HIV, France and overseas territories, 1993–2021*

Variable Value
Median age, y (IQR)
 41.3 (33.2–48.8)
Sex
M 352 (63.7)
F 197 (35.6)
Other†
 4 (0.7)
Geographic origin
Mainland France 166 (30)
Western Europe 1 (0.2)
Sub-Saharan Africa 83 (15)
Middle East 2 (0.3)
Asia 6 (1.1)
North America 1 (0.2)
South and Central America 189 (34.2)
Caribbean
 105 (19)
Residence
Mainland France 150 (28.8)
Martinique 17 (3.3)
Guadeloupe 34 (6.5)
French Guiana 318 (61)
Reunion Island
 2 (0.4)
AIDS stage before histoplasmosis
Yes 244 (44.1)
No
 309 (55.9)
On antiretroviral treatment before histoplasmosis
Yes 56 (10.1)
No
 497 (89.9)
Median CD4, cells/mm3 (IQR)
 20 (6–53)
CD4/CD8 ratio >1 at time of histoplasmosis
Yes 29 (5.7)
No
 479 (94.3)
Median viral load at time of histoplasmosis, copies/mL (IQR) 16,480 (485–205,000)

*Values are no. (%) except as indicated. IQR, interquartile range †Other indicates that personal identity is discordant from birth sex.

Main Article

Page created: May 14, 2025
Page updated: June 17, 2025
Page reviewed: June 17, 2025
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