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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 8—August 2025

Dispatch

ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

Masato Hatta1, Gloria P. Larson1, Yasuko Hatta1, Wei Wang, Nannan Jiang, Yu-Jin Jung, Li Wang, Xiaoyu Fan, Brenda M. Calderon, Gaston Bonenfant, Xudong Lin, Chenchen Feng, Dan Cui, Ginger Atteberry, Michael Currier, John Steel, David E. Wentworth, and Bin ZhouComments to Author 
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M. Hatta, Y. Hatta, N. Jiang, L. Wang, X. Fan, B.M. Calderon, X. Lin, D. Cui, G. Atteberry, M. Currier, J. Steel, D.E. Wentworth, B. Zhou); Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA (G.P. Larson, G. Bonenfant, C. Feng); General Dynamics Information Technology, Inc., Falls Church, Virginia, USA (W. Wang, Y.-J. Jung)

Main Article

Figure 1

Sequence comparison of ACE2 proteins among 54 animal species with phylogenetic tree of ACE2 proteins in study of ACE2 receptor usage across animal species by SARS-CoV-2 variants. Protein sequence of ACE2 from various species are aligned at residues in the SARS-CoV-2 spike protein binding interface. Percent identity to human ACE2 was calculated by pairwise alignment of individual ACE2s to human ACE2. Residues differing from human ACE2 residues are highlighted in yellow. Scale bar indicates the number of amino acid substitutions based on ACE2 protein sequences. ACE2, angiotensin-converting enzyme 2.

Figure 1. Sequence comparison of ACE2 proteins among 54 animal species with phylogenetic tree of ACE2 proteins in study of ACE2 receptor usage across animal species by SARS-CoV-2 variants. Protein sequence of ACE2 from various species are aligned at residues in the SARS-CoV-2 spike protein binding interface. Percent identity to human ACE2 was calculated by pairwise alignment of individual ACE2s to human ACE2. Residues differing from human ACE2 residues are highlighted in yellow. Scale bar indicates the number of amino acid substitutions based on ACE2 protein sequences. ACE2, angiotensin-converting enzyme 2.

Main Article

1These authors contributed equally to this article.

Page created: June 16, 2025
Page updated: July 17, 2025
Page reviewed: July 17, 2025
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