Volume 31, Number 8—August 2025
Dispatch
ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
Figure 1

Figure 1. Sequence comparison of ACE2 proteins among 54 animal species with phylogenetic tree of ACE2 proteins in study of ACE2 receptor usage across animal species by SARS-CoV-2 variants. Protein sequence of ACE2 from various species are aligned at residues in the SARS-CoV-2 spike protein binding interface. Percent identity to human ACE2 was calculated by pairwise alignment of individual ACE2s to human ACE2. Residues differing from human ACE2 residues are highlighted in yellow. Scale bar indicates the number of amino acid substitutions based on ACE2 protein sequences. ACE2, angiotensin-converting enzyme 2.
1These authors contributed equally to this article.
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