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Volume 32, Number 10—October 2026

Dispatch

Fatal Infection with Dengue Virus and Avian Orthoavulavirus 1 in Traveler Returning from Saudi Arabia to France, 2025

Maud Salmona, Salomé Schlupmann, Morgane Mailhe, Dorothée Chopin, Quentin Richier, Karine Lacombe, Lila Bouadma, Jean-Francois Timsit, Vincent Bondet, Quentin Le Hingrat, Jérôme Le Goff, Jamie Sugrue, Darragh Duffy, Olivier Schwartz, Michael White, Valérie Paradis, Franck Verdonk, François-Xavier Lescure, and Marie JaspardComments to Author 
Author affiliation: Author affiliations: Hôpital Saint-Louis, Paris, France (M. Salmona, J. Le Goff); Hôpital Saint-Antoine, Paris (S. Schlupmann, D. Chopin, Q. Richier, K. Lacombe, M. Jaspard); Hôpital Bichat Claude-Bernard, Paris (M. Mailhe, F.-X. Lescure); Sorbonne Universite, Paris (Q. Richier, K. Lacombe, F. Verdonk); Assistance Publique—Hopitaux de Paris, Paris (L. Bouadma, J.-F. Timsit, Q. Le Hingrat, V. Paradis, F.-X. Lescure); IAME, INSERM, Université Paris Cité, Paris (L. Bouadma, J.-F. Timsit, F.-X. Lescure); Université Paris Diderot, Paris (J.-F. Timsit, F.-X. Lescure); Institut Pasteur, Paris (V. Bondet, J. Sugrue, D. Duffy, O. Schwartz, M. White)

Main Article

Figure 3

Cytokine concentrations from study of a fatal infection with dengue virus and avian orthoavulavirus 1 in traveler from Saudi Arabia, 2025. A) IFN-α. B) IFN-γ. C) IFN-induced CXCL10. D) IFN-induced CXCL11. E) Pro-inflammatory IL-6. F) Pro-inflammatory TNF-α. We measured concentrations in blood samples from the study patient compared with those from healthy donors. Boxes indicate 95% CI; horizontal bars within boxes indicate median; whiskers indicate ranges; dots indicate individual patient samples. We measured concentrations for interferon-α using single molecule array digital-ELISA using an in-house Simoa bead-based assay on the HD-X platform (Quanterix, https://www.quanterix.com) and multiplexed Luminex assay (R&D Systems, Inc., https://www.rndsystems.com) for other cytokines. We determined p values by Mann-Whitney test. CXCL, C-X-C motif chemokine ligand; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor-α.

Figure 3. Cytokine concentrations from study of a fatal infection with dengue virus and avian orthoavulavirus 1 in traveler from Saudi Arabia, 2025. A) IFN-α. B) IFN-γ. C) IFN-induced CXCL10. D) IFN-induced CXCL11. E) Pro-inflammatory IL-6. F) Pro-inflammatory TNF-α. We measured concentrations in blood samples from the study patient compared with those from healthy donors. Boxes indicate 95% CI; horizontal bars within boxes indicate median; whiskers indicate ranges; dots indicate individual patient samples. We measured concentrations for interferon-α using single molecule array digital-ELISA using an in-house Simoa bead-based assay on the HD-X platform (Quanterix, https://www.quanterix.com) and multiplexed Luminex assay (R&D Systems, Inc., https://www.rndsystems.com) for other cytokines. We determined p values by Mann-Whitney test. CXCL, C-X-C motif chemokine ligand; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor-α.

Main Article

Page created: August 18, 2026
Page updated: September 11, 2026
Page reviewed: September 11, 2026
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