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Volume 32, Number 10—October 2026

Research Letter

Evaluation of Trichodysplasia Spinulosa Polyomavirus in Skin Biopsies, United States

Ivan M. Espinal, Gregory W. Charville, Lauren Lawrence, Ryanne A. Brown, Kerri E. Rieger, and Sebastian Fernandez-PolComments to Author 
Author affiliation: Stanford University, Stanford, California, USA (I.M. Espinal, G.W. Charville, R.A. Brown, K.E. Rieger, S. Fernandez-Pol); Guardant Health, Palo Alto, California, USA (L. Lawrence); Stanford Medicine, Stanford (R.A. Brown, K.E. Rieger)

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Figure

In situ hybridization (RNAscope) (5) for trichodysplasia spinulosa polyomavirus (TSPyV) in tissue samples, United States. A) Positive control tissue from a case of trichodysplasia spinulosa with staining for TSPyV. Original magnification ×200. B) peptidylprolyl isomerase B (PPIB) RNA probe staining on the same control tissue. Original magnification ×400. C) A representative case of inflammatory dermatosis with no staining for TSPyV RNA. Original magnification ×200. D) PPIB RNA probe staining on the same tissue in (C). Original magnification ×200.

Figure. In situ hybridization (RNAscope) (5) for trichodysplasia spinulosa polyomavirus (TSPyV) in tissue samples, United States. A) Positive control tissue from a case of trichodysplasia spinulosa with staining for TSPyV. Original magnification ×200. B) peptidylprolyl isomerase B (PPIB) RNA probe staining on the same control tissue. Original magnification ×400. C) A representative case of inflammatory dermatosis with no staining for TSPyV RNA. Original magnification ×200. D) PPIB RNA probe staining on the same tissue in (C). Original magnification ×200.

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References
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  5. Lawrence  L, Wang  A, Charville  G, Toland  A, Pinsky  B, Natkunam  Y, et al. Trichodysplasia spinulosa polyomavirus endothelial infection, California, USA. Emerg Infect Dis. 2022;28:1935–7. DOIPubMedGoogle Scholar

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Page created: August 13, 2026
Page updated: September 21, 2026
Page reviewed: September 21, 2026
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