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Volume 32, Supplement –Summer 2026

SUPPLEMENT ISSUE
Supplement

Monkeypox Virus Surveillance in Wastewater, North Carolina, USA, October 2023–May 2025

Nicole L. SnyderComments to Author , Thomas Clerkin, Sarah H. Koenigsberg, Mara B. Tate, Ty L. Lautenschlager, Justin Albertson, Emma L. Doran, Erica F. Wilson, Rachel T. Noble, Virginia T. Guidry, and Ariel R. Christensen
Author affiliation: Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA (N.L. Snyder, S.H. Koenigsberg, M.B. Tate, T.L. Lautenschlager, J. Albertson, E.L. Doran, E.F. Wilson, V.T. Guidry, A.R. Christensen); Institute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, North Carolina, USA (T. Clerkin, R.T. Noble); Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (R.T. Noble)

Main Article

Table 2

Diagnostic performance metrics of wastewater monitoring in study of mpox surveillance in wastewater, North Carolina, USA, October 2023–May 2025*

Study TP FP TN FN Sensitivity, % (95% CI) Specificity, % (95% CI) PPV, % (95% CI) NPV, % (95% CI)
Detections above LOD and trace detections 15 32 627 127 10.6 (6.5–16.7) 95.1 (93.2–96.5) 31.9 (20.4–46.2) 83.2 (80.3–85.7)
Detections above LOD only 2 15 644 140 1.4 (0.4–5.0) 97.7 (96.3–98.6) 11.8 (3.3–34.3) 82.1 (79.3–84.7)

*FN, false negative; FP, false positive; LOD, limit of detection; NPV, negative predictive value; PPV, positive predictive value; TN, true negative; TP, true positive.

Abbreviations:

Main Article

Page created: July 14, 2026
Page updated: September 15, 2026
Page reviewed: September 15, 2026
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