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Volume 32, Number 6—June 2026

Research

In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023–2025

Chompoonek Yurayart, Kanokporn Yingchanakiat, Amonrat Thongbai, Orawan Limsivilai, Sathidpak Nantasanti Assawarachan, Tassanee Jaroensong, and Panpicha SattasathuchanaComments to Author 
Author affiliation: Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand

Main Article

Table 2

Antifungal drug susceptibility profiles of 8 antifungal drugs against 1,178 Sporothrix schenckii complex isolates in Thailand, 2023–2025*

Antifungal drug MICs, μg/mL
Range Mode MIC50 MIC90 MIC95 MIC97.5 MIC99
Amphotericin B 0.06–>32 4 (WT) 4 (WT) 8 (non-WT) 8 (non-WT) 8 (non-WT) 16 (non-WT)
Itraconazole 0.06–>32 >32 (non-WT) 8 (non-WT) >32 (non-WT) >32 (non-WT) >32 (non-WT) >32 (non-WT)
Posaconazole 0.06–>32 1 (WT) 1 (WT) >32 (non-WT) >32 (non-WT) >32 (non-WT) >32 (non-WT)
Voriconazole 0.5–>64 64 (WT) 32 (WT) 64 (WT) 64 (WT) >64 (non-WT) >64 (non-WT)
Terbinafine 0.015–>8 1 (WT) 1 (WT) 2 (WT) 4 (WT) 4 (WT) 8 (non-WT)
Ketoconazole 0.015–>8 1 0.5 2 2 2 4
Fluconazole 1–>256 >256 >256 >256 >256 >256 >256
Flucytosine 0.5–>256 64 64 >256 >256 >256 >256

*Mode is the MIC that occurs most frequently. MIC50, MIC90, MIC95, MIC97.5, and MIC99 values are reported as the minimum concentrations of antifungal drugs required to inhibit 50%, 90%, 95%, and 97.5% of the growth of S. schenckii complex isolates. Susceptibility phenotypes were characterized on the basis of available epidemiologic cutoff values (21) and study-specific cutoff value (for terbinafine). Non-WT, non-wild-type; WT, wild-type.

Main Article

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