Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Volume 32, Number 8—August 2026

Emerging Infection Networks Letter

Detection of blaOXA-23–Positive Proteus mirabilis Isolate, United States, 2024

Giulia OraziComments to Author , Porscha Bumpus-White, Alyssa G. Kent, Erin Breaker, Matthew Doucette, Caryn Ivanof, Esther Fortes, Sanjib Bhattacharyya, Nicolas Epie, Susannah L. McKay, Stephen P. LaVoie, and Sarah Sabour
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (G. Orazi, P. Bumpus-White, A.G. Kent, E. Breaker, S.L. McKay, S.P. LaVoie, S. Sabour); Massachusetts State Public Health Laboratory, Department of Public Health, Jamaica Plain, Massachusetts, USA (M. Doucette, C. Ivanof, E. Fortes, S. Bhattacharyya, N. Epie)

Main Article

Figure

Genomic comparisons of blaOXA-23–positive Proteus mirabilis detected in Massachusetts, USA, in 2024 to clinical isolates identified in previous studies. A) Genomic context of blaOXA-23 regions of P. mirabilis isolate detected in Massachusetts (2024DK-00154) and P. mirabilis clinical isolates previously identified in Switzerland (Pm1 and Pm5) and France (VAC). BLASTn (https://blast.ncbi.nlm.nih.gov) was used to identify the best match to the National Center for Biotechnology Information nucleotide database (https://www.ncbi.nlm.nih.gov/nucleotide) of the blaOXA-23-containing region. Genomic region comparison was generated using Easyfig (https://mjsull.github.io/Easyfig). Pink indicates antimicrobial resistance genes; blue indicates insertion sequences and transposon genes; yellow indicates other genes. Grey shading represents percent nucleotide sequence identity as indicated by the key. B) Phylogenetic tree based on core-genome alignment of blaOXA-23–positive P. mirabilis isolate detected in Massachusetts (2024DK-00154, in bold; GenBank accession no. CP194042) and blaOXA-23–positive P. mirabilis clinical isolates previously identified in other countries (GenBank accession nos. GCA_004347585.1a, GCA_004570075.1, GCA_004570775.1, GCA_004570785.1, GCA_008041895.1, GCA_009684595.1, GCA_009684635.1, GCA_030335585.1, GCA_030335605.1, GCA_030336025.1, GCA_039728795.1, GCA_042929925.1; genome assembly sizes min: 3.91 Mb; max: 4.11 Mb; average: 4.00 Mb). Core-genome alignment and construction of a maximum-likelihood tree were performed using Parsnp (https://github.com/marbl/parsnp). Tree was visualized using iTOL (https://itol.embl.de) and rooted at the midpoint. Country and source of isolate collection are specified. Filled blue circles represent sequence type (ST) 142 isolates; empty circles represent non-ST142 isolates. Year of isolate collection is provided when known. Blue box indicates ST142 isolate cluster. Scale bar indicates number of substitutions per nucleotide. Unk, unknown.

Figure. Genomic comparisons of blaOXA-23–positive Proteus mirabilis detected in Massachusetts, USA, in 2024 to clinical isolates identified in previous studies. A) Genomic context of blaOXA-23 regions of P. mirabilis isolate detected in Massachusetts (2024DK-00154) and P. mirabilis clinical isolates previously identified in Switzerland (Pm1 and Pm5) and France (VAC). BLASTn (https://blast.ncbi.nlm.nih.gov) was used to identify the best match to the National Center for Biotechnology Information nucleotide database (https://www.ncbi.nlm.nih.gov/nucleotide) of the blaOXA-23-containing region. Genomic region comparison was generated using Easyfig (https://mjsull.github.io/Easyfig). Pink indicates antimicrobial resistance genes; blue indicates insertion sequences and transposon genes; yellow indicates other genes. Grey shading represents percent nucleotide sequence identity as indicated by the key. B) Phylogenetic tree based on core-genome alignment of blaOXA-23–positive P. mirabilis isolate detected in Massachusetts (2024DK-00154, in bold; GenBank accession no. CP194042) and blaOXA-23–positive P. mirabilis clinical isolates previously identified in other countries (GenBank accession nos. GCA_004347585.1a, GCA_004570075.1, GCA_004570775.1, GCA_004570785.1, GCA_008041895.1, GCA_009684595.1, GCA_009684635.1, GCA_030335585.1, GCA_030335605.1, GCA_030336025.1, GCA_039728795.1, GCA_042929925.1; genome assembly sizes min: 3.91 Mb; max: 4.11 Mb; average: 4.00 Mb). Core-genome alignment and construction of a maximum-likelihood tree were performed using Parsnp (https://github.com/marbl/parsnp). Tree was visualized using iTOL (https://itol.embl.de) and rooted at the midpoint. Country and source of isolate collection are specified. Filled blue circles represent sequence type (ST) 142 isolates; empty circles represent non-ST142 isolates. Year of isolate collection is provided when known. Blue box indicates ST142 isolate cluster. Scale bar indicates number of substitutions per nucleotide. Unk, unknown.

Main Article

Page created: July 11, 2026
Page updated: July 27, 2026
Page reviewed: July 27, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external