Volume 5, Number 2—April 1999
Dispatch
Lack of Association between First Myocardial Infarction and Past Use of Erythromycin, Tetracycline, or Doxycycline
Lisa A. Jackson
, Nicholas L. Smith, Susan R. Heckbert, J. Thomas Grayston, David S. Siscovick, and Bruce M. Psaty
, Nicholas L. Smith, Susan R. Heckbert, J. Thomas Grayston, David S. Siscovick, and Bruce M. Psaty
Table 2
Cumulative duration of prescribed treatment with erythromycin, tetracycline, doxycycline, and the three agents combined, and the risk for incident myocardial infarction
| Drug | Cumulative duration (day)a | Case-patients (n=1796) (%) | Controls (n=4882) (%) | ORb (95% CI) | ORc (95% CI) |
|---|---|---|---|---|---|
| Erythromycin | 0 | 1,266 (70) | 3,493 (72) | 1.0 reference | 1.0 reference |
| 1-14 | 401 (22) | 1,124 (23) | 0.99 (0.87-1.13) | 0.91 (0.79-1.05) | |
| 15-28 | 92 (5) | 182 (4) 1.41 | (1.08-1.82) | 1.18 (0.89-1.54) | |
| 29+ | 37 (2) | 83 (2) | 1.23 (0.83-1.83) | 1.05 (0.69-1.59) | |
| Tetracycline | 0 | 1,507 (84) | 4,149 (85) | 1.0 reference | 1.0 reference |
| 1-14 | 223 (12) | 564 (12) | 1.11 (0.94-1.31) | 1.02 (0.86-1.22) | |
| 15-28 | 39 (2) | 88 (2) | 1.24 (0.84-1.81) | 1.04 (0.69-1.55) | |
| 29+ | 27 (2) | 81 (2) | 0.95 (0.61-1.47) | 0.98 (0.62-1.54) | |
| Doxycycline | 0 | 1,597 (89) | 4,365 (89) | 1.0 reference | 1.0 reference |
| 1-14 | 37 (2) | 86 (2) | 1.18 (0.79-1.74) | 1.06 (0.71-1.59) | |
| 15-28 | 85 (5) | 244 (5) | 0.94 (0.73-1.22) | 0.90 (0.69-1.18) | |
| 29+ | 77 (4) | 187 (4) | 1.10 (0.84-1.45) | 1.17 (0.88-1.56) | |
| Erythromycin | 0 | 1,021 (57) | 2,821 (58) | 1.0 reference | 1.0 reference |
| tetracycline | 1-14 | 422 (24) | 1,178 (24) | 0.99 (0.87-1.14) | 0.93 (0.81-1.07) |
| or doxycycline | 15-28 | 185 (10) | 454 (9) | 1.13 (0.94-1.35) | 0.99 (0.81-1.20) |
| 29+ | 168 (9) | 421 (9) | 1.11 (0.91-1.34) | 1.03 (0.84-1.26) |
Page created: December 10, 2010
Page updated: December 10, 2010
Page reviewed: December 10, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.