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Volume 6, Number 2—April 2000
Dispatch

Erythromycin Resistance in Streptococcus pyogenes in Italy

Matteo Bassetti*Comments to Author , Graziana Manno*, Andrea Collidà*, Alberto Ferrando*, Giorgio Gatti*, Elisabetta Ugolotti*, Mario Cruciani†, and Dante Bassetti*
Author affiliations: *University of Genoa, G. Gaslini Children's Hospital, Genoa, Italy; and †Department of Infectious Diseases, Verona, Italy

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Table 2

Frequency of clarithromycin failure, by susceptibility profile

Patients treated (no.) Treatment failed (%) p value
Erythromycin-susceptible 25 3 (12)
Erythromycin-resistant 19 7 (36.8) 0.07a
- CRb 6 6 (100) 0.0001a
- other phenotypes 13 1 (7.6) 1.0a; 0.0002c
Total 44 10 (22.7)

aFor comparison of percentage of failure with erythromycin-susceptible.
bCR = Constitutive-type resistance.
cFor comparison of percentage of failure between CR and other phenotypes of resistance.

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References
  1. Bisno  AL. Group A streptococcal infections and acute rheumatic fever. N Engl J Med. 1991;325:78393.PubMed
  2. Kaplan  EL. The resurgence of group A streptococcal infections and their sequelae. Eur J Clin Microbiol Infect Dis. 1991;10:557. DOIPubMed
  3. Moses  AE, Ziv  A, Harari  M, Rahav  G, Shapiro  M, Englehard  D. Increased incidence and severity of Streptococcus pyogenes bacteremia in young children. Pediatr Infect Dis J. 1995;14:76770. DOIPubMed
  4. Peter  G. Streptococcal pharyngitis: current therapy and criteria for evaluation of new agents. Clin Infect Dis. 1992;14(Suppl 2):S21823.PubMed
  5. Schito  GC, Pesce  A, Marchese  AJ. The role of macrolides in Streptococcus pyogenes pharyngitis. J Antimicrob Chemother. 1997;39:5625. DOIPubMed
  6. Lowbury  EJL, Hurst  L. The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin and spiramycin. J Clin Pathol. 1959;12:1634. DOIPubMed
  7. Maruyama  S, Yoshiota  H, Fujita  K, Takimoto  M, Satake  Y. Sensitivity of group A streptococci to antibiotics. Am J Dis Child. 1979;133:1514.PubMed
  8. Seppala  H, Nissinen  A, Jarvinen  H, Huovinen  S, Henriksson  T, Herva  E, Resistance to erythromycin in group A streptococci. N Engl J Med. 1992;326:2927.PubMed
  9. Hsueh  PR, Chen  HM, Huang  AH, Wu  JJ. Decreased activity of erythromycin against Streptococcus pyogenes in Taiwan. Antimicrob Agents Chemother. 1995;39:223942.PubMed
  10. Stingemore  N, Francis  GRJ, Toohey  M, McGechie  DB. The emergence of erythromycin resistance in Streptococcus pyogenes in Fremantle, Western Australia. Med J Aust. 1989;150:62631.PubMed
  11. Gentry  JL, Burns  WW. Antibiotic resistant streptococci. Am J Dis Child. 1980;133:801.
  12. Garcia-Bermejo  I, Cacho  J, Orden  B, Alos  J, Gomez-Garces  JL. Emergence of erythromycin-resistant, clindamycin-susceptible Streptococcus pyogenes isolates in Madrid, Spain. Antimicrob Agents Chemother. 1998;42:98990.PubMed
  13. Orden  B, Perez-Trallero  E, Montes  M, Martinez  R. Erythromycin resistance of Streptococcus pyogenes in Madrid. Pediatr Infect Dis J. 1998;17:4703. DOIPubMed
  14. Cornaglia  G, Ligozzi  M, Mazzariol  A, Valentini  M, Orefici  G, Fontana  R. Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993-1995. Emerg Infect Dis. 1996;2:33942. DOIPubMed
  15. Cocuzza  C, Blandino  G, Mattina  R, Nicoletti  F, Nicoletti  G. Antibiotic susceptibility of group A streptococci in 2 Italian cities: Milano and Catania. Microb Drug Resist. 1997;3:37984. DOIPubMed
  16. Cornaglia  G, Ligozzi  M, Mazzariol  A. Resistance of Streptococcus pyogenes to erythromycin and related antibiotics in Italy. Clin Infect Dis. 1998;27(Suppl 1):S8792. DOIPubMed
  17. Bassetti  M, Mantero  E, Gatti  G, Di Biagio  A, Bassetti  D. Streptococcus pyogenes erythromycin resistance in Italy. Emerg Infect Dis. 1999;5:3023. DOIPubMed
  18. Seppala  H, Nissinen  A, Yu  Q, Houvinen  P. Three different phenotypes of erythromycin-resistant Streptococcus pyogenes in Finland. J Antimicrob Chemother. 1993;32:88591. DOIPubMed
  19. Sutcliffe  J, Tait-Kamradt  A, Wondrack  L. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob Agents Chemother. 1996;40:181724.PubMed
  20. National Committee for Clinical Laboratory Standard Performance Standards for antimicrobial disk susceptibility tests. Document M2- A6. Villanova (PA): The Committee; 1997.
  21. National Committee for Clinical Laboratory Method for dilution for antimicrobial susceptibility tests for bacteria that grow aerobically. Document M7- A4. Villanova (PA): The Committee; 1997.
  22. Sanders  E, Foster  MT, Scott  D. Group A beta-hemolytic streptococci resistant to erythromycin and lincomycin. N Engl J Med. 1968;278:53840.PubMed
  23. Phillips  G, Parratt  D, Orange  GV, Harper  I, McEwan  H, Young  N. Erythromycin resistant Streptococcus pyogenes. J Antimicrob Chemother. 1990;25:7234. DOIPubMed
  24. Lode  H, Boeckh  M, Scaberg  T. Human pharmacokinetics of macrolide antibiotics. In: Macrolides. Chemistry, pharmacology and clinical uses. Bryskier A, Butzler JP, Neu HC, Tulkens PM, editors. Paris: Arnette Blackwell; 1993; p. 409-20.

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