Volume 7, Number 2—April 2001
THEME ISSUE
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections
State of the Art
Molecular Approaches to Diagnosing and Managing Infectious Diseases: Practicality and Costs
Michael A. Pfaller
Table 1
FDA-approved molecular diagnostic tests for infectious diseasea
| Test | Method | Companyb |
|---|---|---|
| Chlamydia trachomatis detection | PCRc LCR TMA Hybrid capture | Roche Abbott Gen-Probe Digene |
| Neisseria gonorrhoeae detection | LCR Hybrid capture | Abbott Digene |
| C. trachomatis/N. gonorrhoeae screening/detection | Hybridization SDR | Gen-Probe Becton-Dickinson |
| Mycobacterium tuberculosis detection | PCR TMA | Roche Gen-Probe |
| HPV screening | Hybrid capture | Digene |
| CMV | Hybrid capture NASBA | Digene Organon Teknika |
| Grp A strep detection | Hybridization | Gen-Probe |
| HIV quantitation | PCR | Roche |
| Gardnerella, T. vaginalis, and Candida | Hybridization | Becton-Dickinson |
| Culture confirmation for bacteria and fungi | Hybridization | Gen-Probe |
aThe table contains examples of commercially available methods and is not intended to be all-inclusive. Websites of the principle manufacturers are a useful source of the most up-to-date information.
bCompanies: Digene, Silver Spring, MD; Chiron, Emeryville, CA; Roche, Branchburg, NJ; Organon Teknika, Durham, NC; Murex/Abbott, Abbott Park, IL; Gen-Probe, San Diego, CA; Abbott, Abbott Park, IL; Becton-Dickinson, Cockeysville, MD.
cPCR = polymerase chain reaction; LCR = ligase chain reaction; TMA = transcription-mediated amplification; SDR = strand displacement reaction; NASBA = nucleic acid strand-based amplification.
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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