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Volume 7, Number 2—April 2001
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections

State of the Art

Molecular Approaches to Diagnosing and Managing Infectious Diseases: Practicality and Costs

Michael A. PfallerComments to Author 
Author affiliation: University of Iowa College of Medicine, Iowa City, Iowa, USA

Main Article

Table 1

FDA-approved molecular diagnostic tests for infectious diseasea

Test Method Companyb
Chlamydia trachomatis detection PCRc
Hybrid capture Roche
Neisseria gonorrhoeae detection LCR
Hybrid capture Abbott
C. trachomatis/N. gonorrhoeae 
screening/detection Hybridization
SDR Gen-Probe
Mycobacterium tuberculosis detection PCR
TMA Roche
HPV screening Hybrid capture Digene
CMV Hybrid capture
NASBA Digene
Organon Teknika
Grp A strep detection Hybridization Gen-Probe
HIV quantitation PCR Roche
Gardnerella, T. vaginalis, and Candida Hybridization Becton-Dickinson
Culture confirmation for bacteria and fungi Hybridization Gen-Probe

aThe table contains examples of commercially available methods and is not intended to be all-inclusive. Websites of the principle manufacturers are a useful source of the most up-to-date information.
bCompanies: Digene, Silver Spring, MD; Chiron, Emeryville, CA; Roche, Branchburg, NJ; Organon Teknika, Durham, NC; Murex/Abbott, Abbott Park, IL; Gen-Probe, San Diego, CA; Abbott, Abbott Park, IL; Becton-Dickinson, Cockeysville, MD.
cPCR = polymerase chain reaction; LCR = ligase chain reaction; TMA = transcription-mediated amplification; SDR = strand displacement reaction; NASBA = nucleic acid strand-based amplification.

Main Article