Volume 7, Number 2—April 2001
THEME ISSUE
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections
State of the Art
Molecular Approaches to Diagnosing and Managing Infectious Diseases: Practicality and Costs
Michael A. Pfaller
Table 1
FDA-approved molecular diagnostic tests for infectious diseasea
| Test | Method | Companyb |
|---|---|---|
| Chlamydia trachomatis detection | PCRc LCR TMA Hybrid capture | Roche Abbott Gen-Probe Digene |
| Neisseria gonorrhoeae detection | LCR Hybrid capture | Abbott Digene |
| C. trachomatis/N. gonorrhoeae screening/detection | Hybridization SDR | Gen-Probe Becton-Dickinson |
| Mycobacterium tuberculosis detection | PCR TMA | Roche Gen-Probe |
| HPV screening | Hybrid capture | Digene |
| CMV | Hybrid capture NASBA | Digene Organon Teknika |
| Grp A strep detection | Hybridization | Gen-Probe |
| HIV quantitation | PCR | Roche |
| Gardnerella, T. vaginalis, and Candida | Hybridization | Becton-Dickinson |
| Culture confirmation for bacteria and fungi | Hybridization | Gen-Probe |
aThe table contains examples of commercially available methods and is not intended to be all-inclusive. Websites of the principle manufacturers are a useful source of the most up-to-date information.
bCompanies: Digene, Silver Spring, MD; Chiron, Emeryville, CA; Roche, Branchburg, NJ; Organon Teknika, Durham, NC; Murex/Abbott, Abbott Park, IL; Gen-Probe, San Diego, CA; Abbott, Abbott Park, IL; Becton-Dickinson, Cockeysville, MD.
cPCR = polymerase chain reaction; LCR = ligase chain reaction; TMA = transcription-mediated amplification; SDR = strand displacement reaction; NASBA = nucleic acid strand-based amplification.
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