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Volume 7, Number 3—June 2001


Is High Prevalence of Echinococcus multilocularis in Wild and Domestic Animals Associated with Disease Incidence in Humans?

Bruno Gottstein*Comments to Author , Francis Saucy†, Peter Deplazes‡, Juerg Reichen*, Georges Demierre§, Andre Busato*, Christian Zuercher*, and Paul Pugin¶
Author affiliations: *University of Bern, Bern, Switzerland; †University of Fribourg, Fribourg, Switzerland; ‡University of Zürich, Zürich, Switzerland; §Medecin Cantonal, Fribourg, Switzerland; ¶Centre de Transfusion Sanguin, Hôpital Cantonal, Fribourg, Switzerland

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Table 3

Specific seroprevalences for Echinococcus multilocularis in blood donorsa

No. (%) [95%-CI]
Blood donors tested (total) 2,943
Em2-positive blood donorsb 6b (0.2) [0.04-0.36]
EgHF-positive blood donors but negative by Em2 33c (1.1) [0.5-2.1]

aAssessed primarily by Em2-enzyme-linked immunosorbent assay (ELISA), complementary serologic data were obtained with the E. granulosus hydatid fluid antigen-ELISA. Blood samples were collected from October 1996 to July 1997.
bFour of six Em2-positive blood donors received imaging investigations, one of which was computed tomography-positive for an alveolar hydatid disease (AHD) lesion. Two Em2-positive donors refused subsequent imaging investigations but have had no signs of AHD.
cTen donors with high E. granulosus hydatid fluid antigen-titers but negative in Em2-ELISA were selected for pilot imaging investigations. One had a cystic hepatic lesion of 2.5 cm in diameter. Morphologic features were compatible with those of E. granulosus cysts.

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