Volume 8, Number 5—May 2002
Research
Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium
Table 2
Two-year relative death rate of patients infected with Salmonella Typhimurium, by antimicrobial susceptibility pattern. Registry linkage study including 2,047 patients and a random matched sample of 20,456 people from the Danish general population
| Resistant | Susceptiblea | ||||
|---|---|---|---|---|---|
| Deaths/cases | RRb (95% CIc) | Deaths/cases | RR (95% CI) | p-valued | |
| Resistant to >1 drug | 31/1,094 | 2.4 (1.6–3.7) | 28/953 | 2.3 (1.5-3.5) | 0.86 |
| Ampicillin | 13/393 | 3.5 (1.7-7.2) | 46/1,654 | 2.1 (1.5-3.0) | 0.21 |
| Chloramphenicol | 16/347 | 5.1 (2.6-10.2) | 43/1,700 | 1.9 (1.4-2.8) | 0.01 |
| Streptomycin | 13/458 | 2.1 (1.1-4.1) | 46/1,589 | 2.4 (1.7-3.4) | 0.76 |
| Sulfonamides | 31/969 | 2.5 (1.6-3.9) | 28/1,078 | 2.1 (1.4-3.3) | 0.60 |
| Tetracycline | 15/513 | 2.2 (1.2-4.1) | 44/1,534 | 2.4 (1.7-3.4) | 0.85 |
| Kanamycin | 3/108 | 23/1,018 | 3.9 (2.2-6.7) | ||
| Quinolone | 5/83 | 10.3(2.8-37.8) | 54/1,964 | 2.1 (1.6-3.0) | 0.02 |
| R-type ACSSuT | 12/283 | 4.8 (2.2-10.5) | 47/1,764 | 2.1 (1.5-2.9) | 0.06 |
| R-type ACSSuTNx | 5/40 | 13.1 (3.3-51.9) | 7/243e | 2.9 (1.1-7.9) | 0.09 |
aSusceptible refers to strains susceptible to the given antimicrobial drugs or combination of antimicrobial drugs; first cell refers to pansusceptible strains.
bDeath rate relative to the general population, as estimated by conditional proportional hazards regression analysis, controlling for underlying illness; RR=rate ratio.
cCI=confidence interval.
dp-value for test of homogeneity, i.e., RR for resistant being the same as for susceptible strains.
eStrains with R-type ACSSuT, but quinolone sensitve.